Camussi G, Mariano F, Biancone L, Montrucchio G, Vercellone A
Cattedra di Nefrologia Sperimentale, Università di Napoli, Italy.
Kidney Int Suppl. 1993 Jan;39:S32-6.
Resident glomerular cells have complex cytoskeletal organizations relevant to maintaining functional and structural integrity. The ability of cells to change shape, develop coordinate directed movements, replicate and interact with contiguous cells or extracellular matrix depends on cytoskeletal functions. Several cytokines directly or indirectly change cytoskeletal organization. Cytokines may alter cytoskeletal organization in cultured glomerular epithelial and mesangial cells and vascular endothelial cells mainly by mechanisms involving production of secondary mediators, such as PAF and leukotrienes that stimulate cell contraction, or PGE2 and PGI2 that stimulate cell relaxation. Consequent assembly and disassembly of microfilaments leads to functional responses of cells that may account for the physiopathological changes induced by cytokines in vivo.
肾小球固有细胞具有与维持功能和结构完整性相关的复杂细胞骨架组织。细胞改变形状、产生协调定向运动、复制以及与相邻细胞或细胞外基质相互作用的能力取决于细胞骨架的功能。几种细胞因子可直接或间接改变细胞骨架组织。细胞因子可能主要通过涉及产生次级介质的机制来改变培养的肾小球上皮细胞、系膜细胞和血管内皮细胞中的细胞骨架组织，这些次级介质如刺激细胞收缩的血小板活化因子（PAF）和白三烯，或刺激细胞舒张的前列腺素E2（PGE2）和前列环素（PGI2）。微丝随后的组装和解聚导致细胞的功能反应，这可能解释了细胞因子在体内诱导的生理病理变化。
