Kakeji Y, Maehara Y, Korenaga D, Tsujitani S, Haraguchi M, Watanabe A, Orita H, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Surg Oncol. 1993 Apr;52(4):207-12. doi: 10.1002/jso.2930520402.
DNA ploidy of tumor cells and the degree of infiltration of dendritic cells were determined in 93 gastric cancer tissue specimens, and the mechanisms of tumor-host interaction on the prognosis were investigated. DNA ploidy patterns were grouped into low and high ploidy, and the degree of infiltration of dendritic cells (DC) was graded into marked and slight infiltration. In the low ploidy group, the 5-year survival rates in patients with marked and slight DC infiltration were 80.7% and 61.5%, respectively (P < 0.05). In the high ploidy group, however, there were no significant differences. In cases of low ploidy, the incidence of lymph node metastasis was significantly lower in the marked DC infiltration group compared with findings in the slight DC group. Thus, markedly infiltrating dendritic cells in gastric cancer tissue may lead to prolongation of survival time for patients with a carcinoma of the low ploidy profile, by preventing widespread nodal involvement.
对93例胃癌组织标本测定肿瘤细胞的DNA倍体和树突状细胞浸润程度，并研究肿瘤-宿主相互作用对预后的影响机制。DNA倍体模式分为低倍体和高倍体，树突状细胞（DC）浸润程度分为显著浸润和轻度浸润。在低倍体组中，DC显著浸润和轻度浸润患者的5年生存率分别为80.7%和61.5%（P<0.05）。然而，在高倍体组中，两者无显著差异。在低倍体情况下，DC显著浸润组的淋巴结转移发生率明显低于轻度DC组。因此，胃癌组织中显著浸润的树突状细胞可能通过防止广泛的淋巴结受累，延长低倍体癌患者的生存时间。
