Korenaga D, Okamura T, Saito A, Baba H, Sugimachi K
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Cancer. 1988 Jul 15;62(2):309-13. doi: 10.1002/1097-0142(19880715)62:2<309::aid-cncr2820620214>3.0.co;2-#.
DNA ploidy microspectrophotometrically determined in 254 patients with gastric carcinoma was investigated from the standpoint of tumor invasion, lymph node metastasis, and prognosis. DNA distribution patterns were grouped into low and high ploidies. The 24.0% frequency in the high ploidy group, at the mucosal stage, increased in proportion to invasion into the deeper layers. There was a high incidence of lymph node metastasis in the high ploidy group, compared with the low ploidy group, in case of invasion beyond the mucosa. Widespread nodal involvement was frequent in the high ploidy group. The 5-year survival rate was 73.7% in patients of high ploidy, with a statistical difference compared to the 90.6% in those of low ploidy (P less than 0.01). In the multivariate analysis of 226 patients undergoing curative surgery, the DNA ploidy proved to be a major independent prognostic factor. These findings indicate a close correlation among DNA ploidy, tumor invasion and nodal involvement, and the significant clinical value of DNA analysis for predicting the prognosis in patients with gastric carcinoma.
从肿瘤浸润、淋巴结转移及预后的角度，对254例胃癌患者经显微分光光度法测定的DNA倍体进行了研究。DNA分布模式分为低倍体和高倍体。在黏膜期，高倍体组的频率为24.0%，其随着向深层浸润而按比例增加。在肿瘤浸润超过黏膜层的情况下，与低倍体组相比，高倍体组淋巴结转移的发生率较高。高倍体组广泛的淋巴结受累很常见。高倍体患者的5年生存率为73.7%，与低倍体患者的90.6%相比有统计学差异（P<0.01）。在对226例行根治性手术患者的多因素分析中，DNA倍体被证明是一个主要的独立预后因素。这些发现表明DNA倍体、肿瘤浸润和淋巴结受累之间密切相关，以及DNA分析对预测胃癌患者预后具有重要的临床价值。
