Chen C K, Chang D Y, Chang S C, Lee E F, Huang S C, Chow S N
Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Republic of China.
Obstet Gynecol. 1993 May;81(5 ( Pt 2)):867-9.
Cryptococcal infection is opportunistic and occurs most commonly in immunocompromised patients. Meningitis is the most frequent manifestation and causes marked morbidity and mortality. Other sites are less common. We report a case of vaginal cryptococcal infection.
A 72-year-old patient who had undergone resection of the colon for cancer 9 years earlier was noted to have a suspicious lesion on the right vaginal wall after an abnormal Papanicolaou test. Biopsy of the lesion showed findings compatible with cryptococcal infection. Serial examinations revealed no evidence of systemic infection or immunocompromised condition. Empirical treatment was tried with fluconazole. Follow-up colposcopy showed almost complete disappearance of the vaginal lesion, and histologic section and culture of the tissue failed to reveal cryptococcus.
Cryptococcal infection is rare, especially in a patient with no evidence of an immunocompromised condition. The preliminary result of fluconazole treatment was satisfactory. However, further follow-up and evaluation are needed to confirm the effectiveness of fluconazole in our patient.
隐球菌感染是机会性感染，最常见于免疫功能低下的患者。脑膜炎是最常见的表现形式，会导致显著的发病率和死亡率。其他部位感染则较为少见。我们报告一例阴道隐球菌感染病例。
一名72岁患者，9年前因癌症接受了结肠切除术，在巴氏试验异常后，右侧阴道壁发现一个可疑病变。病变活检结果显示与隐球菌感染相符。系列检查未发现全身感染或免疫功能低下的证据。尝试使用氟康唑进行经验性治疗。随访阴道镜检查显示阴道病变几乎完全消失，组织学切片和组织培养未发现隐球菌。
隐球菌感染罕见，尤其是在没有免疫功能低下证据的患者中。氟康唑治疗的初步结果令人满意。然而，需要进一步随访和评估以确认氟康唑对我们这位患者的有效性。
