[对辐射敏感的果蝇突变体体细胞中染色体辐射损伤的修饰。半胱胺的辐射防护作用]

[The modification of the radiation damage to the chromosomes in the somatic cells of radiosensitive Drosophila mutants. The radioprotective action of cysteamine].

作者信息

Levina V V, Malinovskiĭ O V

出版信息

Radiobiologiia. 1993 Jan-Feb;33(1):154-9.

Abstract

The radioprotective effect of cysteamine has been studied in larva nerve ganglia of the radiosensitive mutant rad(20)201G1, mutagen-sensitive mutant mus(2)201G1 and the control strain of drosophila. Cysteamine was shown to produce a radioprotective effect in somatic cells of mus(2)201G1 and the control strain of drosophila which was manifested by the decreased incidence of cells with chromosome aberrations and diminished yield of deletions and exchanges. No significant radioprotective effect of cysteamine was observed in somatic cells of rad(2)201G1 mutant.

摘要

已在辐射敏感突变体rad(20)201G1、诱变敏感突变体mus(2)201G1的幼虫神经节以及果蝇对照品系中研究了半胱胺的辐射防护作用。结果表明，半胱胺在mus(2)201G1的体细胞和果蝇对照品系中产生了辐射防护作用，表现为染色体畸变细胞的发生率降低以及缺失和交换的产率降低。在rad(2)201G1突变体的体细胞中未观察到半胱胺的显著辐射防护作用。

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