[Blood plasma content of thyroxine and thyrotropic hormone in Cushing's syndrome and juvenile dyspituitarism syndrome].

The radioimmune method was applied to determination of the thyrotropic hormone (TTH) and thyroxin (T4) in the plasma of 20 patients with Itsenko-Cushing's disease and 12 patients with the syndrome of pubertal-juvenile dyspituitrism. The plasma thyroxin level proved to be lowered in the patients with Itsenko-Cushing's disease (3.1 +/- 0.9 gamma%); it was normal in the patients with the syndrome of pubertal-juvenile dyspituitrism (7.8 +/- 0.9 gamma%). The plasma TTH content gradually decreased in Itsenko-Cushing's disease with the increased duration of the malady. The TTH test demonstrated that the plasma T4 level was much less elevated in 24 hours in Itsenko-Cushing's disease than in the patients with the syndrome of pubertal-juvenile dyspituitrism (by 28 and 86% of the initial level, respectively). The differences in the functional condition of the hypothalamus-hypophysis-thyroid gland system in Itsenko-Cushing's disease and in the pubertal-juvenile dyspituitrism pointed to the different pathogenesis of these diseases.