Kahn J A, Sunde A, von Düring V, Sørdal T, Eriksson N, Molne K
Kvinneklinikken Regionsykehuset i Trondheim.
Tidsskr Nor Laegeforen. 1993 Mar 20;113(8):932-5.
In Norway, the efficacy and the efficiency of IVF treatment for infertile couples have been questioned. Information about this topic is important for the general public, the infertile population, the gynaecologists and the health authorities. We have followed a cohort of 485 infertile couples accepted for in vitro fertilization treatment. During a 14 month period starting 1 January 1989 a total of 214 women have either delivered or are pregnant in the second or third trimester. This number represents 44% of the 485 women accepted for IVF treatment, irrespective of whether they were treated or not, and 50% of the couples who completed at least one IVF cycle. There was no difference in cycle efficiency (pregnancy rate) between the first to third cycle, but this was significantly lower in cycle 4-6. There was no difference in delivery rate between groups of patients with different diagnoses of female infertility, but an additional male factor reduced the delivery rate significantly. Replacement of cryopreserved/thawed embryos gave a 5% increase in the delivery rate per couple included in the study, and an increase of 13% in the number of deliveries.
在挪威，体外受精（IVF）治疗不孕夫妇的疗效和效率受到了质疑。关于这一主题的信息对普通公众、不孕人群、妇科医生和卫生当局都很重要。我们追踪了一组485对接受体外受精治疗的不孕夫妇。从1989年1月1日开始的14个月期间，共有214名女性分娩或处于孕中期或晚期妊娠。这个数字占485名接受IVF治疗女性的44%，无论她们是否接受了治疗，并且占至少完成一个IVF周期夫妇的50%。第一至第三个周期的周期效率（妊娠率）没有差异，但在第4至6个周期显著降低。不同诊断的女性不孕症患者组之间的分娩率没有差异，但男性因素会显著降低分娩率。冷冻/解冻胚胎移植使纳入研究的每对夫妇的分娩率提高了5%，分娩数量增加了13%。
