Mayr A
Lehrstuhl für Mikrobiologie und Seuchenlehre, Tierärztlichen Fakultät, Ludwig-Maximilians-Universität Müncher.
Tierarztl Prax. 1993 Feb;21(1):1-9.
The paraspecific defense system is the phylogenetically older part of the complex immune system. It enables the organism to immediately attack various foreign substances, infectious germs and toxins when confronted by them. In order to activate the paraspecific immune system with the help of drugs, so-called "paramunity inducers" are employed. The use of paramunization is a new way of prophylaxis and therapy, not only with regard to infections, but also with regard to different other indications. The limitations of paramunization are to be found in genetic defects of the paraspecific immune system, therefore the success of paramunization is dependent on the functioning of the paraspecific defense system. The possibility of developing paramunity inducers that are pyrogen-free, non-toxic and pleotypically effective in pre-clinical and clinical experiments is illustrated through the use of pox and parapox viruses. Inducers based on different pox virus species were effective and safe when used in humans as well as in animals in the field.
副特异性防御系统是复杂免疫系统中进化上较古老的部分。它使生物体在遇到各种外来物质、感染性病菌和毒素时能够立即发起攻击。为了借助药物激活副特异性免疫系统，人们使用所谓的“副免疫诱导剂”。副免疫接种的应用是一种新的预防和治疗方法，不仅适用于感染，也适用于其他不同的适应症。副免疫接种的局限性在于副特异性免疫系统的基因缺陷，因此副免疫接种的成功取决于副特异性防御系统的功能。通过使用痘病毒和副痘病毒，说明了在临床前和临床试验中开发无热原、无毒且具有多型性效果的副免疫诱导剂的可能性。基于不同痘病毒种类的诱导剂在实际应用于人类和动物时既有效又安全。
