降钙素基因相关肽：可能作为神经递质对猴子阴茎勃起有作用。

Calcitonin gene-related peptide: possibly neurotransmitter contributes to penile erection in monkeys.

作者信息

Stief C G, Benard F, Bosch R, Aboseif S, Wetterauer U, Lue T F, Tanagho E A

机构信息

Department of Urology, University of California, San Francisco.

出版信息

Urology. 1993 Apr;41(4):397-401. doi: 10.1016/0090-4295(93)90608-d.

DOI:10.1016/0090-4295(93)90608-d

PMID:8470332

Abstract

The distribution of calcitonin gene-related peptide (CGRP) immunoreactivity in the cavernous tissue and the erectile response to intracavernous injection of CGRP was investigated in 7 monkeys. Intracavernous CGRP increased cavernous arterial flow and induced cavernous smooth muscle relaxation and venous outflow occlusion. Intracavernous injection of CGRP antibody did not significantly change the erectile response to cavernous nerve stimulation. Histologic staining for CGRP immunoreactivity showed nerve fiber-like staining within the cavernous arterial wall and the cavernous smooth muscles. These data suggest that CGRP may contribute to penile erection in monkeys.

摘要

在7只猴子中研究了降钙素基因相关肽（CGRP）免疫反应性在海绵体组织中的分布以及海绵体内注射CGRP后的勃起反应。海绵体内注射CGRP可增加海绵体动脉血流，并诱导海绵体平滑肌松弛和静脉流出道阻塞。海绵体内注射CGRP抗体对海绵体神经刺激后的勃起反应无显著影响。CGRP免疫反应性的组织学染色显示在海绵体动脉壁和海绵体平滑肌内有神经纤维样染色。这些数据表明CGRP可能在猴子阴茎勃起中发挥作用。