乙酰胆碱作为神经递质在犬阴茎勃起中的可能作用。

Possible role for acetylcholine as a neurotransmitter in canine penile erection.

作者信息

Stief C, Diederichs W, Benard F, Bosch R, Aboseif S, Lue T F, Tanagho E A

机构信息

Department of Urology, University of California School of Medicine, San Francisco.

出版信息

Urol Int. 1989;44(6):357-63. doi: 10.1159/000281540.

DOI:10.1159/000281540

PMID:2576164

Abstract

In 15 adult dogs, the possible role of acetylcholine as a parasympathetic neurotransmitter in canine penile erection was investigated. Intracavernous injection of increasing dosages of acetylcholine (0.1-100 micrograms) induced a dose-dependent erectile response with increased arterial flow, cavernous smooth muscle relaxation, and venous occlusion. This erectile response was completely abolished after muscarinic blockade by intracavernous injection of 0.1 mg atropine. After cavernous nerve stimulation, atropine injection significantly reduced the pudendal arterial flow (by 25%) and likewise caused a significant reduction in cavernous outflow restriction. Histologic staining showed acetylcholinesterase-positive fibers around the cavernous arteries and within the cavernous erectile tissue.

摘要

在15只成年犬中，研究了乙酰胆碱作为副交感神经递质在犬阴茎勃起中可能发挥的作用。海绵体内注射递增剂量的乙酰胆碱（0.1 - 100微克）可诱导出剂量依赖性的勃起反应，表现为动脉血流增加、海绵体平滑肌松弛和静脉闭塞。在海绵体内注射0.1毫克阿托品进行毒蕈碱阻断后，这种勃起反应完全消失。海绵体神经刺激后，注射阿托品可显著降低阴部动脉血流（降低25%），同样也导致海绵体流出受限显著减少。组织学染色显示海绵体动脉周围和海绵体勃起组织内存在乙酰胆碱酯酶阳性纤维。