Takahashi Y, Ishii N, Lue T F, Tanagho E A
Department of Urology, University of California School of Medicine, San Francisco 94143.
Tohoku J Exp Med. 1991 Sep;165(1):49-58. doi: 10.1620/tjem.165.49.
We investigated the pharmacological effects of adenosine on canine penile erection in vivo. Intracavernous injection of adenosine induced a full erection, which was unaffected by hexamethonium and atropine. The erectile response induced by adenosine was augmented by intracavernous pretreatment with dipyridamole and markedly depressed by theophylline. The erectile response induced by cavernous nerve stimulation was also enhanced by dipyridamole and reduced by theophylline. The combination of acetylcholine and adenosine, when injected intracavernously, induced a full erection, and the effect of these drugs was not additive but synergistic. These results suggest that penile erection induced by adenosine is due to a direct relaxing effect on cavernous smooth muscle. We propose that adenosine plays a cooperative role with acetylcholine and also has a physiological role as a neuromodulator in canine penile erection.
我们研究了腺苷对犬体内阴茎勃起的药理作用。海绵体内注射腺苷可诱导完全勃起，六甲铵和阿托品对此无影响。双嘧达莫海绵体内预处理可增强腺苷诱导的勃起反应，而茶碱则可显著抑制该反应。海绵体神经刺激诱导的勃起反应也可被双嘧达莫增强，被茶碱减弱。乙酰胆碱和腺苷联合海绵体内注射可诱导完全勃起，且这些药物的作用并非相加而是协同的。这些结果表明，腺苷诱导的阴茎勃起是由于其对海绵体平滑肌的直接舒张作用。我们认为，腺苷在犬阴茎勃起中与乙酰胆碱起协同作用，并且作为一种神经调节剂具有生理作用。
