Mili F, Lynch C F, Khoury M J, Flanders W D, Edmonds L D
National Center for Environmental Health, Centers for Disease Control, Atlanta, GA.
Am J Epidemiol. 1993 Mar 15;137(6):639-44. doi: 10.1093/oxfordjournals.aje.a116721.
To attempt to confirm associations found in a companion study in Atlanta, Georgia between Down's syndrome and acute leukemia and between pyloric stenosis and childhood cancer, the authors used the State Health Registry of Iowa to link the records of infants and children with cancer for 1983 to 1989 with the records of infants with birth defects for 1983 to 1988. During the study period, birth defects were diagnosed in 10,891 infants younger than 1 year of age, and cancer was diagnosed in 396 children younger than 8 years of age. The authors compared the observed number of children with a defect who developed cancer with the number expected on the basis of the cancer registry rates. Of the 10,891 children with birth defects, 16 developed cancer (standardized incidence ratio (SIR) = 2.0, 95% confidence interval (CI) 1.2-3.3). Of 251 children with Down's syndrome (trisomy 21), two developed leukemia (SIR = 32.1, 95% CI 3.9-116.0). None of the infants with cancer had pyloric stenosis (SIR = 0.0, 95% CI 0.0-6.7). The results of this study supported the association found in the Atlanta study between Down's syndrome and leukemia, but did not support the association found there between pyloric stenosis and childhood cancer. This study, however, had a shorter follow-up period and a smaller number of subjects than the Atlanta study.
为了尝试证实佐治亚州亚特兰大一项配套研究中发现的唐氏综合征与急性白血病之间以及幽门狭窄与儿童癌症之间的关联，作者利用爱荷华州的州健康登记处，将1983年至1989年患癌症的婴幼儿记录与1983年至1988年有出生缺陷的婴儿记录相联系。在研究期间，10891名1岁以下婴儿被诊断出有出生缺陷，396名8岁以下儿童被诊断出患有癌症。作者将观察到的有缺陷且患癌症的儿童数量与根据癌症登记率预期的数量进行了比较。在10891名有出生缺陷的儿童中，16人患了癌症（标准化发病率（SIR）=2.0，95%置信区间（CI）1.2 - 3.3）。在251名唐氏综合征（21三体）儿童中，2人患了白血病（SIR = 32.1，95%CI 3.9 - 116.0）。患癌症的婴儿中没有一人有幽门狭窄（SIR = 0.0，95%CI 0.0 - 6.7）。这项研究的结果支持了亚特兰大研究中发现的唐氏综合征与白血病之间的关联，但不支持那里发现的幽门狭窄与儿童癌症之间的关联。然而，与亚特兰大研究相比，这项研究的随访期较短，受试者数量较少。
