Department of Epidemiology, SUNY Downstate Medical Center, Brooklyn, New York, USA.
Cancer Invest. 2010 Nov;28(9):958-62. doi: 10.3109/07357907.2010.483510.
The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75–17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P.
研究了癌症患者的亲属中是否存在唇裂伴或不伴腭裂（CL/P）。向 168 名癌症幸存者和 170 名基于人群的健康受试者发放了一份包括癌症家族史和先天性口腔裂畸形家族史的流行病学调查问卷。在对照组中，有 1.2%的人报告有亲属患有 CL/P；而在癌症幸存者中，这一比例为 4.2%（比值比：3.7；95%置信区间：0.75-17.8；p =.07）。与没有 CL/P 家族史的癌症幸存者相比，有 CL/P 家族史的癌症幸存者中睾丸癌和黑色素瘤的发病率明显更高。这些初步结果表明癌症和 CL/P 可能具有共同的病因基础。
