Yamaoka K, Komoto Y, Suzuka I, Edamatsu R, Mori A
Nuclear Safety Section, Central Research Institute of Electric Power Industry, Tokyo, Japan.
Arch Biochem Biophys. 1993 Apr;302(1):37-41. doi: 10.1006/abbi.1993.1177.
We administered radon (Rn) to rabbits by inhalation and examined changes in the lipid peroxide (TBARS) level, superoxide dismutase (SOD) activity, and membrane fluidity in various organs to clarify the therapeutic effects of Rn. The lipid peroxide level of the brain was significantly decreased immediately after Rn inhalation for 90 min in both the low concentration group (about 7-10 kBq/liter) and the high concentration group (about 14-18 kBq/liter) as compared with that in the control group. It further decreased in the low concentration group but slightly recovered in the high concentration group 2 h after inhalation. The lipid peroxide level of the lung showed no change immediately after inhalation but decreased significantly in both groups 2 h after inhalation. With regard to SOD activity in the brain and lung, only that in the brain showed significant increase in the high concentration group immediately after inhalation; no other change was observed. Membrane fluidity, especially the fluidity of membrane protein, was significantly increased in the brains of both groups immediately after inhalation, and that 2 h after inhalation in the lung was significantly increased in both groups. These findings suggest that the inhalation of Rn at Rn springs contributes to the prevention of brain disorders related to peroxidation reactions by promoting these physiologic changes.
我们通过吸入方式给兔子施用氡气（Rn），并检测各器官中脂质过氧化物（TBARS）水平、超氧化物歧化酶（SOD）活性和膜流动性的变化，以阐明Rn的治疗效果。与对照组相比，低浓度组（约7 - 10 kBq/升）和高浓度组（约14 - 18 kBq/升）在吸入Rn 90分钟后，大脑中的脂质过氧化物水平立即显著降低。吸入2小时后，低浓度组的该水平进一步下降，而高浓度组则略有回升。肺部的脂质过氧化物水平在吸入后立即无变化，但在吸入2小时后两组均显著下降。关于大脑和肺部的SOD活性，仅高浓度组在吸入后大脑中的SOD活性立即显著增加；未观察到其他变化。两组在吸入后大脑膜流动性，尤其是膜蛋白的流动性立即显著增加，且在吸入2小时后两组肺部的膜流动性也显著增加。这些发现表明，在氡泉吸入Rn有助于通过促进这些生理变化来预防与过氧化反应相关的脑部疾病。
