Tisljar U
Institut für Biochemie, Universität Stuttgart.
Biol Chem Hoppe Seyler. 1993 Feb;374(2):91-100.
Thimet oligopeptidase (EC 3.4.24.15) is a thiol-dependent metallo-endopeptidase also known as Pz-peptidase, collagenase-like peptidase, endooligopeptidase A, soluble metallo-endopeptidase and endopeptidase 24.15. The enzyme is closely related to the yeast proteinase yscD. Thimet oligopeptidase (M(r) 74000) is widely distributed in animals and plants. In rat liver it exists in a cytoplasmic and mitochondrial form; a membrane-bound form of the enzyme was discovered in rat brain. Thimet oligopeptidase hydrolyses small peptides but does not act on proteins. In rat brain thimet oligopeptidase is involved in the generation of enkephalins and inactivation of bioactive peptides and experiments with yeast provided good evidence that the enzyme is involved in the late stages of cytoplasmatic protein degradation.
思美肽寡肽酶（EC 3.4.24.15）是一种巯基依赖性金属内肽酶，也被称为Pz-肽酶、胶原酶样肽酶、内寡肽酶A、可溶性金属内肽酶和内肽酶24.15。该酶与酵母蛋白酶yscD密切相关。思美肽寡肽酶（分子量74000）广泛分布于动植物中。在大鼠肝脏中，它以细胞质和线粒体形式存在；在大鼠大脑中发现了该酶的膜结合形式。思美肽寡肽酶可水解小肽，但对蛋白质无作用。在大鼠大脑中，思美肽寡肽酶参与脑啡肽的生成和生物活性肽的失活，并且酵母实验提供了充分证据表明该酶参与细胞质蛋白质降解的后期阶段。
