孕期及分娩时的内源性洋地黄样免疫反应性。
Endogenous digoxin-like immunoreactivity during pregnancy and at birth.
作者信息
Lupoglazoff J M, Jacqz-Aigrain E, Guyot B, Chappey O, Blot P
机构信息
Department of Clinical Pharmacology, Hôpital Robert Debré, Paris, France.
出版信息
Br J Clin Pharmacol. 1993 Mar;35(3):251-4.
Abstract
- We have measured endogenous digoxin-like immunoreactivity (EDLI), in mothers and infants, during normal/pathological pregnancies and at birth. 2. During pregnancy, EDLI was measured in 38 maternal-fetal pairs. At the time of fetal sampling, maternal age was 29 (s.d. 6) years and gestational age was 28 (s.d. 6) weeks. EDLI was present in 13 (34%) mothers and in 27 (71%) fetuses. There was no correlation between maternal and fetal concentrations or between maternal or fetal concentrations and gestational age. 3. EDLI was measured at birth in blood samples from 45 maternal-cord pairs. Maternal age was 29 (s.d. 5) years and gestational age was 39 (s.d. 2) weeks. EDLI was present in 11 (22%) maternal and in 44 (98%) cord samples. The concentrations were significantly higher in cord than in fetal or maternal samples (P < 0.001 in both cases). 4. High cord EDLI concentrations suggest acute synthesis during delivery. Thus, the placental transfer of digoxin calculated from maternal and cord digoxin concentrations at birth may be overestimated.
摘要
- 我们在正常/病理妊娠期间及分娩时，测量了母亲和婴儿体内的内源性地高辛样免疫活性（EDLI）。2. 在妊娠期间，对38对母婴进行了EDLI测量。胎儿取样时，母亲年龄为29（标准差6）岁，孕周为28（标准差6）周。13名（34%）母亲和27名（71%）胎儿体内存在EDLI。母亲和胎儿的浓度之间，以及母亲或胎儿的浓度与孕周之间均无相关性。3. 在出生时，对45对母婴的血样进行了EDLI测量。母亲年龄为29（标准差5）岁，孕周为39（标准差2）周。11名（22%）母亲和44名（98%）脐带血样中存在EDLI。脐带血中的浓度显著高于胎儿或母亲血样中的浓度（两种情况P均<0.001）。4. 脐带血中高浓度的EDLI表明分娩期间有急性合成。因此，根据出生时母亲和脐带血中的地高辛浓度计算出的地高辛胎盘转运量可能被高估。
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