Hicks J M, Brett E M
Ther Drug Monit. 1984;6(4):461-4. doi: 10.1097/00007691-198412000-00015.
Several previous studies have suggested the presence of a digoxin-like immunoreactive substance in the serum of infants. In this study we examined eight different immunoassay kits to confirm the presence of such a substance. The kits were evaluated using serum from newborns and infants who were not receiving digoxin. We investigated the relationship of this digoxin-like immunoreactive substance to substances that are present in unusual concentrations in newborn sera. These substances included fatty acids, cholesterol, triglycerides, bilirubin, protein, and albumin. No relationship could be established. Since serum steroid concentrations are known to be increased in the newborn and since digoxin is essentially a steroid derivative, we looked at steroids separately and collectively to see whether they mimicked the immunoreactivity of digoxin. We found that pooled steroids did indeed mimic digoxin and might be implicated as the immunoreactive substances.
此前的多项研究表明，婴儿血清中存在一种地高辛样免疫反应性物质。在本研究中，我们检测了8种不同的免疫分析试剂盒，以确认这种物质的存在。使用未接受地高辛治疗的新生儿和婴儿的血清对试剂盒进行评估。我们研究了这种地高辛样免疫反应性物质与新生儿血清中异常浓度存在的物质之间的关系。这些物质包括脂肪酸、胆固醇、甘油三酯、胆红素、蛋白质和白蛋白。未发现它们之间存在关联。由于已知新生儿血清中类固醇浓度会升高，且地高辛本质上是一种类固醇衍生物，我们分别和综合研究了类固醇，以观察它们是否模拟了地高辛的免疫反应性。我们发现，混合类固醇确实模拟了地高辛，可能是免疫反应性物质。
