Structure elucidation of a novel acidic tetrasaccharide and hexasaccharide derived from a chemically modified heparin.

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作者信息

Desai U R, Wang H M, Kelly T R, Linhardt R J

机构信息

Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City 52242.

出版信息

Carbohydr Res. 1993 Mar 17;241:249-59. doi: 10.1016/0008-6215(93)80112-r.

DOI:10.1016/0008-6215(93)80112-r

PMID:8472255

Abstract

摘要

相似文献

Structure elucidation of a novel acidic tetrasaccharide and hexasaccharide derived from a chemically modified heparin.

Carbohydr Res. 1993 Mar 17;241:249-59. doi: 10.1016/0008-6215(93)80112-r.

A major common trisulfated hexasaccharide core sequence, hexuronic acid(2-sulfate)-glucosamine(N-sulfate)-iduronic acid-N-acetylglucosamine-glucuronic acid-glucosamine(N-sulfate), isolated from the low sulfated irregular region of porcine intestinal heparin.从猪肠道肝素低硫酸化不规则区域分离出的一种主要常见三硫酸化六糖核心序列，即己糖醛酸（2-硫酸酯）-葡糖胺（N-硫酸酯）-艾杜糖醛酸-N-乙酰葡糖胺-葡糖醛酸-葡糖胺（N-硫酸酯）。

J Biol Chem. 1998 Jan 23;273(4):1863-71. doi: 10.1074/jbc.273.4.1863.

Substrate specificity of the heparin lyases from Flavobacterium heparinum.来自肝素黄杆菌的肝素裂解酶的底物特异性。

Arch Biochem Biophys. 1993 Nov 1;306(2):461-8. doi: 10.1006/abbi.1993.1538.

Isolation of the porcine heparin tetrasaccharides with glucuronate 2-O-sulfate. Heparinase cleaves glucuronate 2-O-sulfate-containing disaccharides in highly sulfated blocks in heparin.具有葡萄糖醛酸2-O-硫酸酯的猪肝素四糖的分离。肝素酶可切割肝素中高度硫酸化区域内含有葡萄糖醛酸2-O-硫酸酯的二糖。

J Biol Chem. 1995 Apr 14;270(15):8696-705.

Structure determination of the octa- and decasaccharide sequences isolated from the carbohydrate-protein linkage region of porcine intestinal heparin.从猪肠肝素的碳水化合物-蛋白质连接区域分离出的八糖和十糖序列的结构测定。

J Biol Chem. 1995 Sep 29;270(39):22914-23. doi: 10.1074/jbc.270.39.22914.

Isolation and characterization of hexasaccharides derived from heparin. Analysis by HPLC and elucidation of structure by 1H NMR.肝素衍生六糖的分离与表征。通过高效液相色谱法分析及通过核磁共振氢谱解析结构。

Carbohydr Res. 1995 Jan 3;266(1):37-52. doi: 10.1016/0008-6215(94)00247-d.

Structural studies on the tri- and tetrasaccharides isolated from porcine intestinal heparin and characterization of heparinase/heparitinases using them as substrates.从猪肠肝素中分离得到的三糖和四糖的结构研究以及以它们为底物对肝素酶/类肝素酶的表征。

Glycobiology. 1994 Feb;4(1):69-78. doi: 10.1093/glycob/4.1.69.

Study of structurally defined oligosaccharide substrates of heparin and heparan monosulfate lyases.肝素和硫酸乙酰肝素单硫酸酯酶的结构明确的寡糖底物研究。

Carbohydr Res. 1989 Jul 15;190(2):219-33. doi: 10.1016/0008-6215(89)84127-8.

Specificity studies on the heparin lyases from Flavobacterium heparinum.来自肝素黄杆菌的肝素裂解酶的特异性研究。

Biochemistry. 1993 Aug 17;32(32):8140-5. doi: 10.1021/bi00083a012.

Heparinase II from Flavobacterium heparinum. HPLC analysis of the saccharides generated from chemically modified heparins.来自肝素黄杆菌的肝素酶II。化学修饰肝素产生的糖类的高效液相色谱分析。

Eur J Biochem. 1991 Dec 5;202(2):531-41. doi: 10.1111/j.1432-1033.1991.tb16405.x.

引用本文的文献

Oligosaccharide Chromatographic Techniques for Quantitation of Structural Process-Related Impurities in Heparin Resulting From 2-O Desulfation.用于定量分析肝素中因2-O-脱硫酸作用产生的与结构过程相关杂质的寡糖色谱技术

Front Med (Lausanne). 2018 Dec 18;5:346. doi: 10.3389/fmed.2018.00346. eCollection 2018.

Biologically Relevant Metal-Cation Binding Induces Conformational Changes in Heparin Oligosaccharides as Measured by Ion Mobility Mass Spectrometry.通过离子淌度质谱法测量，与生物相关的金属阳离子结合会诱导肝素寡糖的构象变化。

Int J Mass Spectrom. 2011 Jun 1;303(2-3):191-198. doi: 10.1016/j.ijms.2011.02.003.

Heparan sulfate separation, sequencing, and isomeric differentiation: ion mobility spectrometry reveals specific iduronic and glucuronic acid-containing hexasaccharides.肝素硫酸盐的分离、测序和差向异构体分化：离子淌度谱揭示了特定的含艾杜糖醛酸和葡萄糖醛酸的六糖。

Anal Chem. 2009 Dec 15;81(24):10179-85. doi: 10.1021/ac902186h.

NMR solution conformation of heparin-derived hexasaccharide.肝素衍生六糖的核磁共振溶液构象

Biochem J. 1997 Nov 15;328 ( Pt 1)(Pt 1):51-61. doi: 10.1042/bj3280051.

High-field NMR as a technique for the determination of polysaccharide structures.高场核磁共振作为一种测定多糖结构的技术。

Mol Biotechnol. 1996 Dec;6(3):241-65. doi: 10.1007/BF02761706.

NMR solution conformation of heparin-derived tetrasaccharide.肝素衍生四糖的核磁共振溶液构象

Biochem J. 1996 Aug 15;318 ( Pt 1)(Pt 1):93-102. doi: 10.1042/bj3180093.

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