Gallou G, Ruelland A, Legras B, Maugendre D, Allannic H, Cloarec L
Laboratoire de Biochimie A, Hôpital Sud, Rennes, France.
Clin Chim Acta. 1993 Feb 28;214(2):227-34. doi: 10.1016/0009-8981(93)90114-j.
Malondialdehyde, a marker of lipid peroxidation, was measured as thiobarbituric acid reactive substances (TBARS) in 117 diabetic patients and 53 controls. Patients were divided into groups and subgroups according to the type of diabetes (type 1 and type 2) and the existence or not of vascular complication (macro- or micro-angiopathy). Results showed that TBARS concentrations were significantly higher in type 1 (P < 0.0001) and type 2 (P < 0.001) diabetic patients than in the control group. The plasma TBARS concentrations in type 1 and type 2 diabetic patients did not differ significantly. Among the patients with vascular disease, type 2 diabetic patients with macroangiopathy had significantly higher TBARS concentrations than patients with no vascular complication (P < 0.05). Whichever the type of diabetes, there was no correlation between TBARS concentrations and glycaemic control: glycosylated haemoglobin, fasting blood glucose. This study confirmed the existence of lipid peroxidation disorders in diabetic patients.
丙二醛是脂质过氧化的标志物，在117例糖尿病患者和53例对照者中作为硫代巴比妥酸反应性物质（TBARS）进行测定。患者根据糖尿病类型（1型和2型）以及是否存在血管并发症（大血管或微血管病变）分为组和亚组。结果显示，1型糖尿病患者（P < 0.0001）和2型糖尿病患者（P < 0.001）的TBARS浓度显著高于对照组。1型和2型糖尿病患者的血浆TBARS浓度无显著差异。在患有血管疾病的患者中，患有大血管病变的2型糖尿病患者的TBARS浓度显著高于无血管并发症的患者（P < 0.05）。无论糖尿病类型如何，TBARS浓度与血糖控制指标：糖化血红蛋白、空腹血糖之间均无相关性。本研究证实了糖尿病患者存在脂质过氧化紊乱。
