Aslam Farhan, Iqbal Sanaullah, Nasir Muhammad, Anjum Aftab Ahmad, Swan Pamela, Sweazea Karen
1 Department of Food Science and Human Nutrition, Faculty of Biosciences, University of Veterinary and Animal Sciences Lahore , Lahore, Pakistan .
2 Department of Microbiology, Faculty of Veterinary Sciences, University of Veterinary and Animal Sciences Lahore , Lahore, Pakistan .
J Med Food. 2017 May;20(5):448-457. doi: 10.1089/jmf.2016.0065. Epub 2017 Mar 23.
White sesame seed oil (WSSO) has been used in cooking and food preparations for centuries. It has many purported health benefits and may be a promising nutraceutical. The primary purpose of this study was to examine the effects of WSSO on fasting blood glucose (GLU) and insulin (INS) in male Sprague-Dawley rats with chemically induced diabetes. A secondary aim was to explore other hematological biomarkers of hepatic, cardiac, and renal function. Sixty-three male Sprague-Dawley rats were randomized into standard diet groups, normal control (NCON) (n = 21) and diabetic control (DCON) (n = 21), and a diabetic sesame oil (DSO) (n = 21) group, which were fed a diet containing 12% WSSO. Blood samples were analyzed at 0, 30, and 60 days. Differences between groups and across days were assessed with two-way repeated measures analysis of variance. At baseline, GLU and INS were similar in both diabetic groups, mean 248.4 ± 2.8 mg/dL and mean 23.4 ± 0.4 μU/mL, respectively. At 60 days, GLU was significantly (P < .05) higher in DCON (298.0 ± 2.3 mg/dL) compared with DSO (202.1 ± 1.0 mg/dL). INS showed similar favorable trends after WSSO supplementation. Consumption of WSSO significantly improved glucose control and other biomarkers of hepatic stress, as well as cardiac and renal health. WSSO may be a viable functional food to help reduce the detrimental effects of diabetes.
白芝麻籽油（WSSO）几个世纪以来一直用于烹饪和食品制备。它具有许多所谓的健康益处，可能是一种很有前景的营养保健品。本研究的主要目的是研究WSSO对化学诱导糖尿病的雄性Sprague-Dawley大鼠空腹血糖（GLU）和胰岛素（INS）的影响。次要目的是探索肝脏、心脏和肾脏功能的其他血液学生物标志物。63只雄性Sprague-Dawley大鼠被随机分为标准饮食组，正常对照组（NCON）（n = 21）和糖尿病对照组（DCON）（n = 21），以及糖尿病芝麻油（DSO）组（n = 21），后者喂食含12%WSSO的饮食。在第0、30和60天分析血样。采用双向重复测量方差分析评估组间和不同天数之间的差异。在基线时，两个糖尿病组的GLU和INS相似，分别为平均248.4±2.8mg/dL和平均23.4±0.4μU/mL。在第60天，与DSO组（202.1±1.0mg/dL）相比，DCON组（298.0±2.3mg/dL）的GLU显著更高（P < 0.05）。补充WSSO后，INS也呈现出类似的良好趋势。食用WSSO显著改善了血糖控制以及肝脏应激的其他生物标志物，以及心脏和肾脏健康。WSSO可能是一种可行的功能性食品，有助于减轻糖尿病的有害影响。
