豚鼠离体气管对六种前列腺素反应的比较。

A comparison of responses of guinea-pig isolated trachea to six prostaglandins.

作者信息

Takano S, Sawano A, Watanabe H, Suzuki T

出版信息

Prostaglandins. 1978 Mar;15(3):485-9. doi: 10.1016/0090-6980(78)90132-6.

Abstract

Effects of prostaglandins (PG) E1, E2, F2alpha, A1, A2 and B2 were studied on guinea-pig isolated tracheal chains. PGF2alpha, B2 and A2 produced contraction, PGE1 and E2 relaxation of the chain, but A1 produced no response. 1) From the cumulative dose response curves, PGF2alpha was more active in producing contraction than B2 or A2, though its effect was less than that of acetylcholine (ACh). PGE1-induced relaxation was less than the response to isoproterenol. 2) PGE1 and E2 1 microgram/ml caused a 26.1 +/- 3.83% (n=5) or a 9.5 +/- 3.36 (n=6) decrease of ACh (1 microgram/ml)-induced contraction respectively. The degree of relaxation produced by E1 was greater than that by E2 (P less than 0.01). 3) After five minutes preincubation with each of PGA1, A2, B2 and F2alpha in concentrations which did not produce any effect, ACh-induced contraction was augmented only after PGA2 (P less than 0.05).

摘要

研究了前列腺素（PG）E1、E2、F2α、A1、A2和B2对豚鼠离体气管链的作用。PGF2α、B2和A2使气管链收缩，PGE1和E2使其舒张，但A1无反应。1）从累积剂量反应曲线来看，PGF2α在引起收缩方面比B2或A2更具活性，但其作用小于乙酰胆碱（ACh）。PGE1诱导的舒张小于对异丙肾上腺素的反应。2）PGE1和E2（1微克/毫升）分别使ACh（1微克/毫升）诱导的收缩降低26.1±3.83%（n = 5）或9.5±3.36（n = 6）。E1产生的舒张程度大于E2（P < 0.01）。3）在分别用不产生任何作用的浓度的PGA1、A2、B2和F2α预孵育5分钟后，仅PGA2使ACh诱导的收缩增强（P < 0.05）。