Ison C A, Roope N S, Dangor Y, Radebe F, Ballard R
Department of Medical Microbiology, St Mary's Hospital Medical School, Paddington, London.
Epidemiol Infect. 1993 Apr;110(2):297-305. doi: 10.1017/s0950268800068230.
One hundred and ninety-two strains of Neisseria gonorrhoeae isolated from migrant mine-workers were tested for their susceptibility to antibiotics, auxotyped and serotyped. Of the total, 93 (48%) were acquired locally and 64 (33%) from different geographical locations. Plasmid-mediated resistance to penicillin was found in 28 (14.6%) strains and was associated predominantly with the presence of 5.0 kb penicillinase encoding plasmid (18/28, 64%). Chromosomal resistance to penicillin (MIC > or = 1 mg/l) was detected in 14 (7.3%) strains. Resistance to tetracycline was chromosomally and not plasmid-mediated. Antibiotic resistance was encountered most commonly among strains acquired in Natal. The overall gonococcal population was sensitive to ceftriaxone, ciprofloxacin, spectinomycin and azithromycin. Nine auxotype/serovar (A/S) classes were encountered among penicillinase-producing N. gonorrhoeae (PPNG) compared to 24 A/S classes among non-PPNG strains. The most common A/S class was NR/IA-6 which accounted for 38% of PPNG and 15% of non-PPNG.
对从流动矿工中分离出的192株淋病奈瑟菌进行了抗生素敏感性测试、辅助型别鉴定和血清型别鉴定。其中，93株（48%）是在当地获得的，64株（33%）来自不同地理位置。在28株（14.6%）菌株中发现了质粒介导的青霉素耐药性，主要与5.0 kb编码青霉素酶的质粒的存在有关（18/28，64%）。在14株（7.3%）菌株中检测到对青霉素的染色体耐药性（MIC≥1 mg/l）。对四环素的耐药性是由染色体介导的，而非质粒介导。在纳塔尔获得的菌株中最常出现抗生素耐药性。总体淋球菌群体对头孢曲松、环丙沙星、壮观霉素和阿奇霉素敏感。在产青霉素酶的淋病奈瑟菌（PPNG）中发现了9种辅助型别/血清型（A/S）类别，而非PPNG菌株中有24种A/S类别。最常见的A/S类别是NR/IA-6，占PPNG的38%，非PPNG的15%。
