Kochhar M M, Davidson P P, Bhushan R S
Res Commun Chem Pathol Pharmacol. 1977 Feb;16(2):251-63.
alpha-l-Acetylmethadol is being currently evaluated as a substitute for methadone in the treatment of heroin addicts. The metabolites, isolated from urine, liver, and serum, were identified by gas-liquid chromatography. Methadone and its metabolites were found to be present in urine, liver and serum of rats treated with alpha-l-acetylmethadol. The presence of methadone was confirmed by gas-chromatography-mass spectometry. The purpose of this study was to determine whether alpha-l-acetylmethadol is metabolized to methadone, which might explain in part the longer duration of action of alpha-l-acetylmethadol.
目前正在评估α-1-乙酰美沙多作为美沙酮替代品用于治疗海洛因成瘾者的效果。从尿液、肝脏和血清中分离出的代谢产物通过气液色谱法进行鉴定。在用α-1-乙酰美沙多治疗的大鼠的尿液、肝脏和血清中发现了美沙酮及其代谢产物。通过气相色谱-质谱联用仪确认了美沙酮的存在。本研究的目的是确定α-1-乙酰美沙多是否会代谢为美沙酮，这可能部分解释了α-1-乙酰美沙多作用时间较长的原因。
