Physiological disposition and biotransformation of l-alpha-[2-3H]acetylmethadol (LAAM) in acutely and chronically treated monkeys. - Suppr | 超能文献

Physiological disposition and biotransformation of l-alpha-[2-3H]acetylmethadol (LAAM) in acutely and chronically treated monkeys.

作者信息

Misra A L, Mulé S J, Bloch R, Bates T R

出版信息

J Pharmacol Exp Ther. 1978 Aug;206(2):475-91.

PMID:98628

Abstract

摘要

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。

相似文献

1

Physiological disposition and biotransformation of l-alpha-[2-3H]acetylmethadol (LAAM) in acutely and chronically treated monkeys.

J Pharmacol Exp Ther. 1978 Aug;206(2):475-91.

2

The effect of ethanol on the metabolism of chronically-administered l-alpha-acetylmethadol (LAAM) in the rhesus monkey.

Res Commun Chem Pathol Pharmacol. 1978 Aug;21(2):351-4.

3

Pharmacokinetics and metabolism of l-alpha-[O,O'-3H2]-acetyl normethadol (nor-LAAM), the active metabolite of LAAM, in acutely and chronically treated rhesus monkeys.

J Pharmacol Exp Ther. 1980 Sep;214(3):599-607.

4

Metabolism and disposition of l-alpha-acetylmethadol in the rat.

Drug Metab Dispos. 1977 Jul-Aug;5(4):321-8.

5

Pharmacokinetics and metabolism of (-)-alpha-[2-3H]acetylmethadol (LAAM) in the monkey: evidence for a new metabolite.

J Pharm Pharmacol. 1976 Apr;28(4):316-8. doi: 10.1111/j.2042-7158.1976.tb04164.x.

6

Pharmacology of l-alpha-acetylmethadol (LAAM) in subhuman primates.

Ann N Y Acad Sci. 1978;311:199-213. doi: 10.1111/j.1749-6632.1978.tb16777.x.

7

Comparative study of the electroencephalographic and behavioral effects of l-alpha-acetylmethadol (LAAM), two of its metabolites and morphine and methadone in the rat.大鼠中左旋α-乙酰美沙多（LAAM）、其两种代谢物、吗啡及美沙酮的脑电图和行为效应的比较研究

J Pharmacol Exp Ther. 1980 Nov;215(2):382-9.

8

Metabolism and probable active metabolite of alpha-l-acetylmethadol in rat.大鼠体内α-1-乙酰美沙多的代谢及可能的活性代谢物

Res Commun Chem Pathol Pharmacol. 1977 Feb;16(2):251-63.

9

Brain levels of l-alpha--acetylmethadol (LAAM) and metabolites in the rat: correlation with pharmacological effects.大鼠脑中左旋α-乙酰美沙酮（LAAM）及其代谢物的含量：与药理作用的相关性

Proc West Pharmacol Soc. 1977;20:473-6.

10

Pharmacology of LAAM.

NIDA Res Monogr. 1976 Jul(8):15-28.

引用本文的文献

1

Self administration of cocaine in monkeys receiving LAAM acutely or chronically.急性或慢性接受LAAM的猴子对可卡因的自我给药。

Physiol Behav. 2008 Jan 28;93(1-2):20-6. doi: 10.1016/j.physbeh.2007.07.008. Epub 2007 Jul 28.

2

Blood-brain equilibration kinetics of levo-alpha-acetyl-methadol using a chronically instrumented sheep preparation.使用长期植入仪器的绵羊制备方法研究左旋-α-乙酰美沙多的血脑平衡动力学。

Br J Pharmacol. 2006 Jan;147(2):209-17. doi: 10.1038/sj.bjp.0706470.

3

Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies.细胞色素P450 3A在左-α-乙酰美沙多生物活化及临床效应中的矛盾作用：临床研究对验证体外药物代谢研究的重要性

Clin Pharmacokinet. 2005;44(7):731-51. doi: 10.2165/00003088-200544070-00005.

4

Role of the lung in total body clearance of circulating drugs.肺在循环药物全身清除中的作用。

Clin Pharmacokinet. 1979 Sep-Oct;4(5):355-67. doi: 10.2165/00003088-197904050-00002.