Friedhoff A J, Bonnet K, Tosengarten H
Res Commun Chem Pathol Pharmacol. 1977 Mar;16(3):411-23.
Rats treated chronically with dopamine receptor blockers were found to have an increase in striatal 3H-dopamine binding and adenylate cyclase activity as manifestations of receptor supersensitivity. Both the increase in binding and in adenylate cyclase activity were reversed by chronic 1-dopa treatment, presumably by increasing the supply of specific ligand (dopamine). The use of deliberate receptor sensitivity manipulation may be useful as a treatment for conditions involving disturbances in receptor sensitivity such as tardive dyskinesia and insulin resistant diabetes.
长期接受多巴胺受体阻滞剂治疗的大鼠，其纹状体3H-多巴胺结合及腺苷酸环化酶活性增加，作为受体超敏反应的表现。结合增加及腺苷酸环化酶活性增加，均可被长期左旋多巴治疗逆转，推测是通过增加特异性配体（多巴胺）的供应。有意操纵受体敏感性，可能有助于治疗涉及受体敏感性紊乱的疾病，如迟发性运动障碍和胰岛素抵抗性糖尿病。
