Wang J, Fitzpatrick D W, Wilson J R
Department of Food and Nutrition, University of Manitoba, Winnipeg, Canada.
Food Chem Toxicol. 1993 Mar;31(3):191-7. doi: 10.1016/0278-6915(93)90093-e.
Acute T-2 toxin treatments alter biogenic monoamine concentrations in the brain; however, these perturbations have not been well documented or demonstrated in feeding trials. In this study, the effect of dietary T-2 toxin on regional brain concentrations of biogenic monoamines and their metabolites was investigated in male rats fed a semi-synthetic diet containing 0, 2.5 or 10 ppm T-2 toxin for either 7 or 14 days. Reduction in feed consumption, feed efficiency and weight gain was observed in rats fed either 2.5 or 10 ppm T-2 toxin. This effect was transient in animals fed the 10 ppm T-2 toxin diet, with feed consumption, feed efficiency and weight gain improving significantly during wk 2. T-2 toxin affected brain biogenic monoamine concentrations. In the nucleus raphe magnus, serotonin, 5-hydroxy-3-indoleacetic acid and norepinephrine increased in a dose-dependent manner, and dopamine increased transiently. In the substantia nigra of rats fed 10 ppm T-2, epinephrine increased after 7 days and norepinephrine decreased after 14 days, when compared with controls. Dihydroxyphenylacetic acid concentrations in the paraventricular nucleus and medial forebrain bundle were lower in T-2 toxin-treated rats than in control animals. The observed effects of T-2 toxin on brain monoamines and the resulting neurochemical imbalance may account for the physiological manifestation of trichothecene intoxication.
急性T-2毒素处理会改变大脑中生物源单胺的浓度；然而，在喂养试验中，这些干扰尚未得到充分记录或证实。在本研究中，研究了在含有0、2.5或10 ppm T-2毒素的半合成饲料中喂养7天或14天的雄性大鼠，日粮T-2毒素对大脑各区域生物源单胺及其代谢产物浓度的影响。在喂食2.5或10 ppm T-2毒素的大鼠中观察到采食量、饲料效率和体重增加降低。在喂食10 ppm T-2毒素日粮的动物中，这种影响是短暂的，在第2周采食量、饲料效率和体重增加显著改善。T-2毒素影响大脑生物源单胺浓度。在中缝大核中，血清素、5-羟基-3-吲哚乙酸和去甲肾上腺素呈剂量依赖性增加，多巴胺短暂增加。与对照组相比，喂食10 ppm T-2的大鼠黑质中，肾上腺素在7天后增加，去甲肾上腺素在14天后减少。T-2毒素处理的大鼠室旁核和内侧前脑束中的二羟基苯乙酸浓度低于对照动物。观察到的T-2毒素对大脑单胺的影响以及由此产生的神经化学失衡可能解释了单端孢霉烯中毒的生理表现。
