Fabres C, Zegers-Hochschild F, Altieri E, Llados C
Unit of Reproductive Medicine, Clinica Las Condes Hospital, Santiago, Chile.
Hum Reprod. 1993 Feb;8(2):208-10. doi: 10.1093/oxfordjournals.humrep.a138023.
The purpose of this study was to validate the dual analyte system (Boots Celltech Ltd, Slough, UK) as a marker of ovarian function. For this purpose the urinary profile of the ratio of oestrone-3-glucuronide to pregnanediol-3-glucuronide in urine (E13G/PD3G) was compared with plasma concentrations of oestradiol, progesterone, luteinizing hormone (LH) and follicle stimulating hormone from day 8-24 of the menstrual cycle in 23 women. Daily transvaginal ultrasound was also performed from day 8 of the cycle until sonographic evidence of follicular rupture. The ratio of urinary metabolites exhibited a maximum value close to ovulation. In the majority of cases this coincided with the day of LH peak, and was followed by follicular rupture within the next 24 h in 74% of cases. The assay gives a good marker of ovulation, however, it is unlikely to help in detecting the initiation of the fertile period or the quality of the menstrual cycle.
本研究的目的是验证双分析物系统（英国斯劳市博姿细胞技术有限公司）作为卵巢功能标志物的有效性。为此，对23名女性月经周期第8至24天尿液中雌酮-3-葡萄糖醛酸苷与孕二醇-3-葡萄糖醛酸苷的比例（E13G/PD3G）的尿样谱与血浆中雌二醇、孕酮、促黄体生成素（LH）和促卵泡生成素的浓度进行了比较。从周期第8天开始每天进行经阴道超声检查，直至有卵泡破裂的超声证据。尿代谢物的比例在接近排卵时呈现最大值。在大多数情况下，这与LH峰值日一致，74%的病例在接下来的24小时内出现卵泡破裂。该检测方法可很好地标记排卵，但不太可能有助于检测生育期的开始或月经周期的质量。
