体外受精后未能形成原核的卵母细胞中的不成熟和染色体异常。

Immaturity and chromosomal abnormalities in oocytes that fail to develop pronuclei following insemination in vitro.

作者信息

Almeida P A, Bolton V N

机构信息

Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, Denmark Hill, London, UK.

出版信息

Hum Reprod. 1993 Feb;8(2):229-32. doi: 10.1093/oxfordjournals.humrep.a138028.

DOI:10.1093/oxfordjournals.humrep.a138028

PMID:8473425

Abstract

A total of 293 oocytes that failed to develop pronuclei after insemination in vitro with apparently normal, fertile spermatozoa were obtained from 87 women undergoing therapeutic in-vitro fertilization. The oocytes were investigated cytogenetically to determine the incidence of immaturity and chromosomal abnormalities. Cytogenetic examination was possible in 81% of the preparations, in which immaturity and chromosomal abnormalities were present in 29.5 and 58.7% respectively.

摘要

从87名接受治疗性体外受精的女性中获取了总共293个卵母细胞，这些卵母细胞在与外观正常、有生育能力的精子进行体外受精后未能形成原核。对这些卵母细胞进行了细胞遗传学研究，以确定未成熟和染色体异常的发生率。81%的样本能够进行细胞遗传学检查，其中未成熟和染色体异常的发生率分别为29.5%和58.7%。