Edgar D H, James G B, Mills J A
Unit of Reproductive Medicine, Ninewells Hospital, Dundee, UK.
Hum Reprod. 1993 Feb;8(2):277-8. doi: 10.1093/oxfordjournals.humrep.a138037.
The ability of in-vitro fertilized human embryos to secrete oestradiol in culture in the presence of precursor androgen was demonstrated in four independent cultures. Varying amounts of oestradiol were detected and secretion was observed as early as days 5-8 post-fertilization. The pattern of human chorionic gonadotrophin secretion was similar to oestradiol secretion for individual embryos. In one additional culture, secretion of oestradiol and progesterone was observed.
在四项独立培养实验中证实了体外受精的人类胚胎在存在前体雄激素的情况下于培养中分泌雌二醇的能力。检测到了不同量的雌二醇，并且早在受精后第5 - 8天就观察到了分泌现象。对于单个胚胎而言，人绒毛膜促性腺激素的分泌模式与雌二醇分泌模式相似。在另一项培养实验中，观察到了雌二醇和孕酮的分泌。
