Sibley J T, Blocka K L, Sheridan D P, Olszynski W P
Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
J Rheumatol. 1993 Feb;20(2):299-303.
We describe a family in which 3 members each developed systemic lupus erythematosus complicated by ischemic vasculopathy. The calendar years and patient ages of disease onset and the clinical courses were remarkably similar for all 3 patients, although their genotypes were not. The potential contributions of heredity and environment to the concordance of disease expression in this family are discussed.
我们描述了一个家族，其中3名成员均患系统性红斑狼疮并伴有缺血性血管病。尽管这3名患者的基因型不同，但疾病发病的历年时间、患者年龄及临床病程却非常相似。本文讨论了遗传和环境因素对该家族疾病表现一致性的潜在影响。
