Vaishnavi C, Ganguly N K, Kaur S, Kumar B
Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Microbiol Immunol. 1993;37(1):49-53. doi: 10.1111/j.1348-0421.1993.tb03178.x.
Antibody-dependent cellular cytotoxicity (ADCC) was assessed in mice infected experimentally with Mycobacterium leprae and injected simultaneously with in vitro-formed immune complexes (IC). Significant decrease in the ADCC function was observed in animals given IC at zero day (0dIC) and 3 months (3mIC) post inoculation with M. leprae, when ADCC activity was assessed at 3, 6 and 9 months period. From the data obtained we believe that ADCC is suppressed by IC formed in vitro.
在实验感染麻风分枝杆菌并同时注射体外形成的免疫复合物（IC）的小鼠中评估了抗体依赖性细胞毒性（ADCC）。在接种麻风分枝杆菌后第0天（0dIC）和3个月（3mIC）给予IC的动物中，当在3、6和9个月期间评估ADCC活性时，观察到ADCC功能显著下降。根据获得的数据，我们认为体外形成的IC会抑制ADCC。
