在麻风分枝杆菌感染小鼠体内体外形成的免疫复合物对抗体依赖的细胞介导的细胞毒性作用的抑制
Suppression of ADCC by immune complexes formed in vitro in Mycobacterium leprae-infected mice.
作者信息
Vaishnavi C, Ganguly N K, Kaur S, Kumar B
机构信息
Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Microbiol Immunol. 1993;37(1):49-53. doi: 10.1111/j.1348-0421.1993.tb03178.x.
Antibody-dependent cellular cytotoxicity (ADCC) was assessed in mice infected experimentally with Mycobacterium leprae and injected simultaneously with in vitro-formed immune complexes (IC). Significant decrease in the ADCC function was observed in animals given IC at zero day (0dIC) and 3 months (3mIC) post inoculation with M. leprae, when ADCC activity was assessed at 3, 6 and 9 months period. From the data obtained we believe that ADCC is suppressed by IC formed in vitro.
在实验感染麻风分枝杆菌并同时注射体外形成的免疫复合物（IC）的小鼠中评估了抗体依赖性细胞毒性（ADCC）。在接种麻风分枝杆菌后第0天（0dIC）和3个月（3mIC）给予IC的动物中，当在3、6和9个月期间评估ADCC活性时，观察到ADCC功能显著下降。根据获得的数据，我们认为体外形成的IC会抑制ADCC。
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