麻风分枝杆菌的酚糖脂-I可诱导体外刀豆球蛋白A反应的全面抑制，且与麻风类型无关。
Phenolic glycolipid-I of Mycobacterium leprae induces general suppression of in vitro concanavalin A responses unrelated to leprosy type.
作者信息
Prasad H K, Mishra R S, Nath I
出版信息
J Exp Med. 1987 Jan 1;165(1):239-44. doi: 10.1084/jem.165.1.239.
Abstract
Using a costimulant assay, in vitro Con A responses of patients across the leprosy spectrum were found to be markedly suppressed by phenolic glycolipid-I (PGL-I), a unique antigen of M. leprae. The degree of inducible suppression as well as the number of leprosy patients showing suppression of mitogenic responses was higher with PGL-I as compared with integral M. leprae (p less than 0.05 to less than 0.01). Both untreated lepromatous (60%) as well as tuberculoid leprosy (67%) patients showed significant suppression ranging from 13 to 64% and 12 to 79%, respectively. Thus, PGL-I appears to have a universal suppressive effect on Con A responses and is unlikely to play a central role in determining the leprosy spectrum.
摘要
通过共刺激试验发现，麻风分枝杆菌的独特抗原酚糖脂-I（PGL-I）可显著抑制麻风病各型患者体外对刀豆蛋白A（Con A）的反应。与完整的麻风分枝杆菌相比，PGL-I诱导抑制的程度以及显示有丝分裂原反应受到抑制的麻风病患者数量更高（P值小于0.05至小于0.01）。未经治疗的瘤型麻风患者（60%）以及结核样型麻风患者（67%）均显示出显著抑制，分别为13%至64%和12%至79%。因此，PGL-I似乎对Con A反应具有普遍抑制作用，并且不太可能在决定麻风病谱方面发挥核心作用。
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本文引用的文献
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