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1
Phenolic glycolipid-I of Mycobacterium leprae induces general suppression of in vitro concanavalin A responses unrelated to leprosy type.麻风分枝杆菌的酚糖脂-I可诱导体外刀豆球蛋白A反应的全面抑制，且与麻风类型无关。
J Exp Med. 1987 Jan 1;165(1):239-44. doi: 10.1084/jem.165.1.239.
2
Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid.麻风分枝杆菌独特糖脂诱导的麻风病淋巴细胞抑制作用。
Nature. 1984;308(5955):194-6. doi: 10.1038/308194a0.
3
The serological response to the phenolic glycolipid of Mycobacterium leprae in Australian and Nepali leprosy patients.澳大利亚和尼泊尔麻风病患者对麻风分枝杆菌酚糖脂的血清学反应。
Aust N Z J Med. 1987 Dec;17(6):568-73. doi: 10.1111/j.1445-5994.1987.tb01257.x.
4
The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy.麻风杆菌对麻风病患者淋巴细胞体外增殖反应的抑制作用。
Clin Exp Immunol. 1980 Sep;41(3):406-14.
5
Assessment of the immune deficit in leprosy patients and the effect of recombinant IL-2 in vitro.麻风病患者免疫缺陷的评估及重组白细胞介素-2的体外作用
Int J Lepr Other Mycobact Dis. 1987 Jun;55(2):249-60.
6
Serologic responses to Mycobacterium leprae-specific phenolic glycolipid-I antigen in sooty mangabey monkeys with experimental leprosy.患有实验性麻风病的黑掌蛛猴对麻风分枝杆菌特异性酚糖脂-I抗原的血清学反应。
Int J Lepr Other Mycobact Dis. 1988 Dec;56(4):537-45.
7
IgA antibodies against phenolic glycolipid I from Mycobacterium leprae in serum of leprosy patients and contacts: subclass distribution and relation to disease activity.麻风病患者及其接触者血清中针对麻风分枝杆菌酚糖脂I的IgA抗体：亚类分布及其与疾病活动的关系。
Clin Immunol Immunopathol. 1989 Nov;53(2 Pt 1):202-11. doi: 10.1016/0090-1229(89)90050-0.
8
Mycobacterium leprae antigen-induced suppression of T cell proliferation in vitro.麻风分枝杆菌抗原在体外诱导T细胞增殖抑制。
J Immunol. 1987 May 1;138(9):3028-34.
9
The role of Mycobacterium leprae phenolic glycolipid I (PGL-I) in serodiagnosis and in the pathogenesis of leprosy.麻风分枝杆菌酚糖脂I（PGL-I）在麻风病血清学诊断及发病机制中的作用。
Lepr Rev. 2011 Dec;82(4):344-57.
10
Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae.麻风分枝杆菌酚糖脂-I肽模拟表位的产生与特性分析
FEMS Immunol Med Microbiol. 2004 May 1;41(1):51-7. doi: 10.1016/j.femsim.2004.01.001.

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Dr. Indira Nath: Innovator in Leprosy Immunology and a Beacon of Scientific Excellence.英迪拉·纳特博士：麻风病免疫学领域的创新者与科学卓越的灯塔。
Cureus. 2024 Aug 26;16(8):e67796. doi: 10.7759/cureus.67796. eCollection 2024 Aug.
2
Modulation of the cytokine response in human monocytes by mycobacterium leprae phenolic glycolipid-1.麻风分枝杆菌酚糖脂-1 对人单核细胞细胞因子反应的调节。
J Interferon Cytokine Res. 2012 Jan;32(1):27-33. doi: 10.1089/jir.2011.0044. Epub 2011 Oct 7.
3
Cytokine quantification in the supernatant of mononuclear cell cultures and in blood serum from patients with Jorge Lobo's disease.对患有 Jorge Lobo 病患者的单核细胞培养上清液和血清中的细胞因子进行定量分析。
Mycopathologia. 2004 Jul;158(1):17-24. doi: 10.1023/b:myco.0000038433.76437.ec.
4
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Infect Immun. 2002 Sep;70(9):5167-76. doi: 10.1128/IAI.70.9.5167-5176.2002.
5
Mycobacterial di-O-acyl-trehalose inhibits mitogen- and antigen-induced proliferation of murine T cells in vitro.分枝杆菌二 - O - 酰基海藻糖在体外抑制丝裂原和抗原诱导的小鼠T细胞增殖。
Clin Diagn Lab Immunol. 2001 Nov;8(6):1081-8. doi: 10.1128/CDLI.8.6.1-91-1088.2001.
6
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J Bacteriol. 1996 Jan;178(2):456-61. doi: 10.1128/jb.178.2.456-461.1996.
7
Definition of a human suppressor T-cell epitope.人类抑制性T细胞表位的定义。
Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9456-60. doi: 10.1073/pnas.91.20.9456.
8
Immunological study of the defined constituents of mycobacteria.分枝杆菌特定成分的免疫学研究。
Springer Semin Immunopathol. 1988;10(4):279-300. doi: 10.1007/BF02053841.
9
Influence of Mycobacterium leprae and its soluble products on the cutaneous responsiveness of leprosy patients to antigen and recombinant interleukin 2.麻风分枝杆菌及其可溶性产物对麻风病人皮肤对抗抗原及重组白细胞介素2反应性的影响
Proc Natl Acad Sci U S A. 1989 Aug;86(16):6269-73. doi: 10.1073/pnas.86.16.6269.
10
In vitro suppression of interleukin 2 production by Mycobacterium leprae antigen.麻风杆菌抗原对白细胞介素2产生的体外抑制作用。
Clin Exp Immunol. 1989 Jun;76(3):398-403.

本文引用的文献

1
The suppressive effect of M. leprae on the in vitro proliferative responses of lymphocytes from patients with leprosy.麻风杆菌对麻风病患者淋巴细胞体外增殖反应的抑制作用。
Clin Exp Immunol. 1980 Sep;41(3):406-14.
2
Aberrant immunoregulatory control of B lymphocyte function in lepromatous leprosy.瘤型麻风病中B淋巴细胞功能的异常免疫调节控制
Clin Exp Immunol. 1982 Jul;49(1):105-14.
3
Monocyte-derived soluble suppressor factor(s) in patients with lepromatous leprosy.瘤型麻风患者单核细胞衍生的可溶性抑制因子
Infect Immun. 1983 Dec;42(3):890-9. doi: 10.1128/iai.42.3.890-899.1983.
4
Studies on T cell subsets and functions in leprosy.麻风病中T细胞亚群及功能的研究。
Clin Exp Immunol. 1981 Jun;44(3):491-500.
5
Natural suppressor cells in human leprosy: the role of HLA-D-identical peripheral lymphocytes and macrophages in the in vitro modulation of lymphoproliferative responses.人类麻风病中的自然抑制细胞：HLA - D相同的外周淋巴细胞和巨噬细胞在体外调节淋巴细胞增殖反应中的作用。
Clin Exp Immunol. 1980 Nov;42(2):203-10.
6
Serological activity of a characteristic phenolic glycolipid from Mycobacterium leprae in sera from patients with leprosy and tuberculosis.麻风分枝杆菌特征性酚糖脂在麻风病和结核病患者血清中的血清学活性。
Clin Exp Immunol. 1983 May;52(2):271-9.
7
Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid.麻风分枝杆菌独特糖脂诱导的麻风病淋巴细胞抑制作用。
Nature. 1984;308(5955):194-6. doi: 10.1038/308194a0.
8
Generation and characterization of monoclonal antibodies to the phenolic glycolipid of Mycobacterium leprae.麻风分枝杆菌酚糖脂单克隆抗体的产生及特性鉴定
Infect Immun. 1984 Jan;43(1):183-8. doi: 10.1128/iai.43.1.183-188.1984.
9
Inhibition of interleukin-2 production by adherent cell factors from lepromatous leprosy patients.瘤型麻风患者贴壁细胞因子对白细胞介素-2产生的抑制作用。
Clin Exp Immunol. 1984 Dec;58(3):531-8.
10
Studies on the defect in cell-mediated immunity in lepromatous leprosy using HLA-D-identical siblings. Absence of circulating suppressor cells and evidence that the defect is in the T-lymphocyte, rather than the monocyte, population.利用 HLA - D 相同的同胞对瘤型麻风病细胞介导免疫缺陷的研究。循环抑制细胞的缺失以及缺陷存在于 T 淋巴细胞而非单核细胞群体的证据。
Scand J Immunol. 1982 Jan;15(1):33-48. doi: 10.1111/j.1365-3083.1982.tb00619.x.

麻风分枝杆菌的酚糖脂-I可诱导体外刀豆球蛋白A反应的全面抑制，且与麻风类型无关。

Phenolic glycolipid-I of Mycobacterium leprae induces general suppression of in vitro concanavalin A responses unrelated to leprosy type.

作者信息

Prasad H K, Mishra R S, Nath I

出版信息

J Exp Med. 1987 Jan 1;165(1):239-44. doi: 10.1084/jem.165.1.239.

DOI:10.1084/jem.165.1.239
PMID:3540178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188247/
Abstract

Using a costimulant assay, in vitro Con A responses of patients across the leprosy spectrum were found to be markedly suppressed by phenolic glycolipid-I (PGL-I), a unique antigen of M. leprae. The degree of inducible suppression as well as the number of leprosy patients showing suppression of mitogenic responses was higher with PGL-I as compared with integral M. leprae (p less than 0.05 to less than 0.01). Both untreated lepromatous (60%) as well as tuberculoid leprosy (67%) patients showed significant suppression ranging from 13 to 64% and 12 to 79%, respectively. Thus, PGL-I appears to have a universal suppressive effect on Con A responses and is unlikely to play a central role in determining the leprosy spectrum.

摘要

通过共刺激试验发现，麻风分枝杆菌的独特抗原酚糖脂-I（PGL-I）可显著抑制麻风病各型患者体外对刀豆蛋白A（Con A）的反应。与完整的麻风分枝杆菌相比，PGL-I诱导抑制的程度以及显示有丝分裂原反应受到抑制的麻风病患者数量更高（P值小于0.05至小于0.01）。未经治疗的瘤型麻风患者（60%）以及结核样型麻风患者（67%）均显示出显著抑制，分别为13%至64%和12%至79%。因此，PGL-I似乎对Con A反应具有普遍抑制作用，并且不太可能在决定麻风病谱方面发挥核心作用。