Forastiere E M, Belcastro F, Iacovacci V, Greco R
Servizio di Anestesia e Rianimazione, Ospedale Cristo Re, Roma.
Minerva Anestesiol. 1993 Jan-Feb;59(1-2):41-8.
Buprenorphine was used as a preanesthetic drug for peridural anaesthesia. The aim of the study was therefore to evaluate the sedative/anxiolitic activity of this drug as compared to prometazine and diazepam. Two hundred male patients, divided into two groups (A and B), who were to undergo urological surgery under peripheral anesthesia, were included in the study: L2/L3 or L3/L4 epidural block. The group A patients were premedicated with buprenorphine; the group B patients received traditional anesthetic. The following factors were evaluated: the course of the AP and CF, the state of intraoperative sedation, the presence of side effects and data obtained, elaborated with a statistical test constructed to compare the percentages in two independent samples. There were no statistically significant variations of the AP and CF in the two groups. Additional sedatives were administered to 56.2% of the patients in group B and to only 27.1% in group A, premedicated with buprenorphine. Thirty seven percent of the group A patients and 10% of the group B patients presented preoperative nausea. The authors believe that the buprenorphine/atrophine association should be encouraged for pre-anesthesia when operations in peridural anesthesia are to be conducted, as it provides a state of constant sedation, avoiding rather ineffective pharmacological mixtures.
丁丙诺啡用作硬膜外麻醉的术前用药。因此，本研究的目的是评估该药物与异丙嗪和地西泮相比的镇静/抗焦虑活性。200名男性患者被纳入研究，他们将接受外周麻醉下的泌尿外科手术：L2/L3或L3/L4硬膜外阻滞，并分为两组（A组和B组）。A组患者术前用丁丙诺啡进行预处理；B组患者接受传统麻醉。评估以下因素：动脉压（AP）和中心静脉压（CF）的变化过程、术中镇静状态、副作用的出现情况以及所获得的数据，并使用构建的统计检验进行分析，以比较两个独立样本中的百分比。两组的AP和CF无统计学上的显著差异。B组56.2%的患者和用丁丙诺啡预处理的A组仅27.1%的患者需要额外给予镇静剂。A组37%的患者和B组10%的患者出现术前恶心。作者认为，当进行硬膜外麻醉手术时，应鼓励将丁丙诺啡/阿托品联合用于麻醉前准备，因为它能提供持续的镇静状态，避免使用效果不佳的药物组合。
