Block F, Kunkel M, Schwarz M
Department of Neurology, University of Essen, FRG.
Neurosci Lett. 1993 Jan 12;149(2):126-8. doi: 10.1016/0304-3940(93)90752-7.
Injection of quinolinic acid (QA) into the striatum of rats is known to produce neuropathological and neurochemical alterations similar to those observed in Huntington's disease (HD). One clinical feature of HD patients is cognitive impairment. Two weeks after stereotaxic injection of either QA (240 nmol) or solvent in rats spatial learning was tested in the Morris water maze. QA lesioned animals required more time to find the hidden platform. The swim speed was reduced in all trials compared to the controls. The swim distance itself was longer and the amount of swim distance along the side wall was significantly higher in QA lesioned rats. The present results suggest that QA lesion of the striatum leads to deficit in motor performance and in spatial learning.
已知向大鼠纹状体注射喹啉酸（QA）会产生与亨廷顿舞蹈病（HD）中观察到的类似的神经病理学和神经化学改变。HD患者的一个临床特征是认知障碍。在大鼠立体定向注射QA（240纳摩尔）或溶剂两周后，在莫里斯水迷宫中测试空间学习能力。QA损伤的动物找到隐藏平台需要更多时间。与对照组相比，在所有试验中游泳速度均降低。QA损伤大鼠的游泳距离本身更长，沿着侧壁的游泳距离量显著更高。目前的结果表明，纹状体的QA损伤会导致运动表现和空间学习能力缺陷。
