Simpson L O, Murdoch J C, Herbison G P
Department of General Practice, University of Otago Medical School, Dunedin.
N Z Med J. 1993 Mar 24;106(952):104-7.
To investigate the possibility of a correlation between the percentage of nondiscocytic erythrocytes and muscle fatiguability in subjects with the symptom of chronic tiredness.
Sixty nine volunteers suffering from persisting or intermittent tiredness and 72 healthy controls provided 3-drop samples of venous blood for red cell shape analysis before and after inducing fatigue in the trigger finger muscles by repeatedly pulling the trigger of an antique revolver. Elapsed time and the number of pulls were recorded. A work index was calculated from the number of trigger pulls divided by the time in seconds then multiplied by the number of trigger pulls.
Subjects with tiredness had fewer discoid cells (males 62.5% vs 69.2%, p = 0.029; females 65.8% vs 71.8%, p = 0.002) than controls. They also had fewer trigger pulls (males 62.3 vs 84.0, p = 0.003; females 29.5 vs 36.8, p = 0.042) and lower "work indices" (males 75.6 vs 104.7, p = 0.001; females 26.1 vs 39.6, p = 0.001) than controls at the first trigger pulling. After 5 minutes rest the number of trigger pulls for males was fewer than the controls (56.0 vs 64.2) but the difference was not significant, but the female values (24.3 vs 33.2) were significantly different (p = 0.008). Work indices for both sexes were significantly different from controls (males p = 0.020, females p = 0.001).
The association of increased nondiscocytes and impaired muscle function could indicate a cause and effect relationship. This would be in agreement with the physiological concept of fatigue as a consequence of inadequate oxygen delivery.
研究慢性疲劳症状患者中非盘状红细胞百分比与肌肉疲劳性之间存在相关性的可能性。
69名患有持续性或间歇性疲劳的志愿者以及72名健康对照者，在通过反复拉动古董左轮手枪扳机诱导扳机指肌肉疲劳前后，提供3滴静脉血样本用于红细胞形态分析。记录所用时间和拉动次数。根据拉动次数除以时间（秒）再乘以拉动次数计算工作指数。
与对照组相比，疲劳患者的盘状细胞较少（男性62.5%对69.2%，p = 0.029；女性65.8%对71.8%，p = 0.002）。在首次拉动扳机时，他们的拉动次数也较少（男性62.3次对84.0次，p = 0.003；女性29.5次对36.8次，p = 0.042），“工作指数”也较低（男性75.6对104.7，p = 0.001；女性26.1对39.6，p = 0.001）。休息5分钟后，男性的拉动次数少于对照组（56.0次对64.2次），但差异不显著，而女性的值（24.3次对33.2次）有显著差异（p = 0.008）。两性的工作指数均与对照组有显著差异（男性p = 0.020，女性p = 0.001）。
非盘状红细胞增加与肌肉功能受损之间的关联可能表明存在因果关系。这与因氧气输送不足导致疲劳的生理概念相符。
