Kelleher K J, Casey P H, Bradley R H, Pope S K, Whiteside L, Barrett K W, Swanson M E, Kirby R S
Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock 72202.
Pediatrics. 1993 May;91(5):941-8.
To determine the epidemiology, clinical characteristics, and outcomes for low birth weight (LBW) infants with growth deficiency, or failure to thrive (FTT, the term commonly used by pediatric providers to describe growth deficiency or faltering in early childhood).
Three-year prospective cohort study with matched case-control study of outcomes.
Eight large university hospital sites throughout the United States.
914 LBW infants inborn at the sites and meeting study criteria.
FTT was a common condition in this cohort, with 180 (19.7%) of 914 LBW infants meeting case criteria by 30 months. New cases of FTT peaked at 8 months gestation-corrected age. In addition to expected differences in growth between infants with and without FTT, infants with FTT had lower developmental indices and less stimulating home environments. At 36 months, FTT infants had lower IQ scores and were much smaller than infants without FTT.
Growth deficiency, or FTT, is a common clinical condition for those involved in the follow-up care of LBW infants. Worse cognitive and growth outcomes were observed for those meeting the restrictive case criteria employed in this study. More than 80% of the cases in this LBW cohort did not involve any chronic medical disorders, but several biological and environmental differences were found between those who developed FTT and those who did not.
确定出生体重低（LBW）且生长发育迟缓或发育不良（FTT，儿科医生常用该术语描述幼儿期生长发育迟缓或发育停滞）婴儿的流行病学特征、临床特点及转归。
为期三年的前瞻性队列研究，并对转归进行匹配病例对照研究。
美国八家大型大学医院。
在这些地点出生且符合研究标准的914例低出生体重婴儿。
发育不良在该队列中是一种常见情况，914例低出生体重婴儿中有180例（19.7%）在30个月时符合病例标准。发育不良的新病例在孕龄校正年龄8个月时达到峰值。除了发育不良婴儿与未发育不良婴儿在生长方面的预期差异外，发育不良婴儿的发育指标较低，家庭环境的刺激性也较小。在36个月时，发育不良婴儿的智商得分较低，且比未发育不良的婴儿小得多。
生长发育迟缓或发育不良是参与低出生体重婴儿随访护理人员所面临的常见临床情况。对于符合本研究采用的严格病例标准的婴儿，观察到更差的认知和生长转归。在这个低出生体重队列中，超过80%的病例不涉及任何慢性疾病，但在发生发育不良的婴儿和未发生发育不良的婴儿之间发现了一些生物学和环境方面的差异。
