Wilkinson G, Allen P, Marshall E, Walker J, Browne W, Mann A H
London Hospital Medical College.
Psychol Med. 1993 Feb;23(1):229-37. doi: 10.1017/s0033291700039027.
This pilot study demonstrated the feasibility of providing practice nurse support as an adjunct to standard general practitioner treatment to patients with depressive disorders prescribed antidepressant medication. With respect to the measures used and pilot study objectives identified, there were no statistically significant differences between the study groups in treatment adherence to the prescription of antidepressant medication or in the incidence and severity of adverse events to medication. Large-scale randomized controlled trials are in progress to assess the effectiveness of practice nurse interventions in the management of depressive illness in general practice.
这项试点研究证明了为正在服用抗抑郁药物的抑郁症患者提供执业护士支持作为标准全科医生治疗辅助手段的可行性。就所采用的测量方法和确定的试点研究目标而言，研究组在抗抑郁药物处方的治疗依从性或药物不良事件的发生率和严重程度方面没有统计学上的显著差异。大规模随机对照试验正在进行中，以评估执业护士干预在全科医疗中管理抑郁症的有效性。
