Zaider M
Center for Radiological Research, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
Radiat Res. 1993 Apr;134(1):1-8.
The purpose of this paper is to describe mathematically the observed dependence of the number of DNA single-strand breaks (SSBs) per unit dose on radiation quality (e.g., LET) by invoking the concept of matrix saturation (i.e., the fact that a nucleotide can be the site of one SSB only and therefore further local energy deposition is wasted), and to show that, based on this, one obtains a characteristic variation of the yield of DNA double-strand breaks with variation of LET, in qualitative agreement with certain experimental determinations. The formalism developed here makes use of methodology from the field of integral geometry, introduced by Kellerer [Radiat. Prot. Dosim. 31, 9-16, 1990] in microdosimetry.
本文的目的是通过引入矩阵饱和的概念（即一个核苷酸只能是一个单链断裂的位点，因此进一步的局部能量沉积被浪费），以数学方式描述单位剂量下DNA单链断裂（SSB）数量对辐射品质（例如传能线密度）的观测依赖性，并表明基于此，随着传能线密度的变化可得到DNA双链断裂产额的特征变化，这与某些实验测定结果在定性上是一致的。本文所建立的形式体系利用了积分几何领域的方法，该方法由凯勒勒[《辐射防护剂量学》31卷，9 - 16页，1990年]在微剂量学中引入。
