Hankes L V, De Bruin E, Jansen C R, Vorster L, Schmaeler M
S Afr Med J. 1977 Mar 19;51(12):383-90.
Six South African White miners were studied with the 2-g L-tryptophan load test and tracer doses of L-tryptophan-7a-14C, L-kynurenine-keto-14C and hydroxy-L-kynurenine-keto-14C. The breath 14CO2 and 14 urinary metabolities were measured. When they were compared with a previous study of American women with scleroderma, similar 14CO2 and tryptophan metabolite excretion patterns were observed in the data from the miners. The labelled quinolinic acid excretion was more significantly elevated in the South African miners' urine than in the urine of the American women. The data from both studies suggest that some patients with scleroderma have an altered step in the tryptophan metabolic pathway after hydroxy-anthranilic acid. What relationship exists between the induction of pulmonary silicosis and the subsequent development of scleroderma, requires additional human studies.
对6名南非白人矿工进行了2克L-色氨酸负荷试验，并使用示踪剂量的L-色氨酸-7α-14C、L-犬尿氨酸-酮-14C和羟基-L-犬尿氨酸-酮-14C进行研究。测量了呼出的14CO2和14种尿液代谢产物。当将这些数据与之前对美国硬皮病女性患者的研究进行比较时，在矿工的数据中观察到了相似的14CO2和色氨酸代谢产物排泄模式。与美国女性的尿液相比，南非矿工尿液中标记的喹啉酸排泄量显著更高。两项研究的数据均表明，一些硬皮病患者在羟基邻氨基苯甲酸之后的色氨酸代谢途径中存在改变的步骤。肺硅沉着病的诱发与随后硬皮病的发展之间存在何种关系，还需要更多人体研究。
