Askenasy J J
Sleep Research Institute, Sheba Medical Center, Tel-Aviv University, Israel.
Acta Neurol Scand. 1993 Mar;87(3):167-70. doi: 10.1111/j.1600-0404.1993.tb04095.x.
Two major sources of dissatisfaction with the quality of life among Parkinsonian patients are the "locomotor disability" and the "nature of their sleep". The main focus of research was directed towards the locomotor disability, but in the last two decades some progress has been made towards the understanding of sleep in PD patients. Sleep in Parkinson's disease is light and fragmented due to an increased skeletal muscle activity, disturbed breathing, impaired biological rhythm and REM-nonREM variations of the dopaminergic receptor sensitivity.
帕金森病患者对生活质量不满意的两个主要原因是“运动功能障碍”和“睡眠状况”。研究的主要重点一直是运动功能障碍，但在过去二十年里，在理解帕金森病患者的睡眠方面取得了一些进展。帕金森病患者的睡眠浅且碎片化，这是由于骨骼肌活动增加、呼吸紊乱、生物节律受损以及多巴胺能受体敏感性的快速眼动-非快速眼动变化所致。
