Boczarska-Jedynak Magdalena, Opala Grzegorz
Katedra i Klinika Neurologii Wieku Podeszłego, Slaska Akademia Medyczna, SP CSK, ul. Medyków 14, 40-752 Katowice.
Neurol Neurochir Pol. 2005 Sep-Oct;39(5):380-8.
Parkinson's disease is a progressive disorder of the central nervous system. Degeneration of the dopaminergic neurons is the main cause of the disease. The basic symptoms of Parkinson's disease are bradykinesia, rigidity and resting tremor. Disturbances of the autonomous nervous system, depression, dementia and sleep disorders are common, too. People with Parkinson's disease suffer from insomnia, excessive daytime sleepiness, "sleep attacks", nightmares, REM sleep behaviour disorder, periodic limb movement in sleep, restless legs syndrome and sleep apnea syndrome. The main cause of sleep disorders in Parkinson's disease are age-connected changes in sleep architecture, disturbances of neurotransmission, movement disturbances in sleep, medications and concomitant diseases. The authors present the current state of knowledge on sleep disorders in Parkinson's disease, especially, the role of dopaminergic therapy, methods of diagnostics and treatment as well as the influence of sleep disturbances on patient's quality of life.
帕金森病是一种中枢神经系统的进行性疾病。多巴胺能神经元的变性是该疾病的主要病因。帕金森病的基本症状是运动迟缓、僵硬和静止性震颤。自主神经系统紊乱、抑郁、痴呆和睡眠障碍也很常见。帕金森病患者会出现失眠、日间过度嗜睡、“睡眠发作”、噩梦、快速眼动睡眠行为障碍、睡眠期周期性肢体运动、不宁腿综合征和睡眠呼吸暂停综合征。帕金森病睡眠障碍的主要原因是与年龄相关的睡眠结构变化、神经传递紊乱、睡眠中的运动障碍、药物治疗及伴发疾病。作者介绍了帕金森病睡眠障碍的当前知识状态,特别是多巴胺能治疗的作用、诊断和治疗方法以及睡眠障碍对患者生活质量的影响。