Bakheit A M, Behan P O, Watson W S, Morton J J
Department of Neurology, University of Glasgow, Scotland.
Acta Neurol Scand. 1993 Mar;87(3):234-8. doi: 10.1111/j.1600-0404.1993.tb04108.x.
Water metabolism and the responses of the neurohypophysis to changes in plasma osmolality during the water loading and water deprivation tests were studied in nine patients with postviral fatigue syndrome (PVFS) and eight age and six-matched healthy control subjects. Secretion of arginine-vasopressin (AVP) was erratic in these patients as shown by lack of correlation between serum and urine osmolality and the corresponding plasma AVP levels. Patients with PVFS had significantly low baseline arginine-vasopressin levels when compared with healthy subjects. Patients with PVFS as a group also showed evidence of increased total body water content. These results may be indicative of hypothalamic dysfunction in patients with PVFS.
对9例病毒性疲劳综合征（PVFS）患者以及8名年龄匹配和6名性别匹配的健康对照者进行了研究，观察他们在水负荷和禁水试验期间的水代谢情况以及神经垂体对血浆渗透压变化的反应。这些患者的精氨酸加压素（AVP）分泌不稳定，血清和尿渗透压与相应血浆AVP水平之间缺乏相关性即可证明。与健康受试者相比，PVFS患者的精氨酸加压素基线水平显著较低。PVFS患者作为一个群体，也显示出体内总含水量增加的迹象。这些结果可能表明PVFS患者存在下丘脑功能障碍。
