Virtaniemi J, Laakso M, Nuutinen J, Karjalainen S, Vartiainen E
Department of Otolaryngology, University of Kuopio, Finland.
Acta Otolaryngol. 1993 Mar;113(2):123-7. doi: 10.3109/00016489309135779.
Eye movement tests (saccade tests: reaction time, peak velocities and accuracy, and the eye tracking test) were studied in 53 insulin-dependent diabetic (IDDM) patients and 42 randomly selected non-diabetic control subjects, aged between 20 and 40 years. All subjects had central visual acuity of at least 0.1 in one eye, and none had ophthalmoplegia. The reaction time was longer and the accuracy decreased in the saccade test in diabetic patients as compared to control subjects. Peak velocities tended to be slower in diabetic patients, but no significant differences between diabetic and non-diabetic subjects were observed. The maximum eye movement velocities were reduced at all target velocities in diabetic patients as compared to control subjects. These findings can be explained on the basis of many potential disturbances in the central nervous system. Only the duration of diabetes had a clear association with maximum smooth pursuit eye movement velocities in the eye tracking test. Microvascular complications (retinopathy, nephropathy), autonomic neuropathy or metabolic control (high fasting blood glucose and glycated hemoglobin A1c) had no clear association with the results of eye movement tests. In conclusion, insulin dependent diabetes mellitus deteriorates the visuomotor responses.
对53名年龄在20至40岁之间的胰岛素依赖型糖尿病（IDDM）患者和42名随机选取的非糖尿病对照受试者进行了眼动测试（扫视测试：反应时间、峰值速度和准确性，以及眼动追踪测试）。所有受试者单眼中心视力至少为0.1，且均无眼肌麻痹。与对照受试者相比，糖尿病患者扫视测试中的反应时间更长，准确性降低。糖尿病患者的峰值速度往往较慢，但糖尿病和非糖尿病受试者之间未观察到显著差异。与对照受试者相比，糖尿病患者在所有目标速度下的最大眼动速度均降低。这些发现可以基于中枢神经系统中的许多潜在干扰来解释。在眼动追踪测试中，只有糖尿病病程与最大平稳跟踪眼动速度有明确关联。微血管并发症（视网膜病变、肾病）、自主神经病变或代谢控制（高空腹血糖和糖化血红蛋白A1c）与眼动测试结果无明确关联。总之，胰岛素依赖型糖尿病会使视觉运动反应恶化。
