Alessandrini M, Paris V, Bruno E, Giacomini P G
Department of Biopathology and Diagnostic of Imaging, University of Rome Tor Vergata, Italy.
Doc Ophthalmol. 1999;99(1):11-20. doi: 10.1023/a:1002464316347.
The aim of this study was to evaluate whether a correlation existed between saccadic eye movements and visual pathways function in diabetic patients. Saccadic or fast Eye Movement System (EMS) and Visual Evoked Potentials (VEPs) were assessed in 20 insulin-dependent diabetic mellitus (IDDM) patients without long-term complications and in stable metabolic control and in 21 age-matched control subjects. In IDDM patients we observed significantly (p<0.01) longer EMS latency, while EMS velocity and accuracy were similar to those of controls; VEPs showed a significant delay in N75, P100, N145 latencies and significant reduction of N75-P100 and P100-N145 amplitudes. In IDDM patients no relationships between EMS and VEP parameters were found. In conclusion, EMS latency delay suggests an impairment of the saccadic eye movement system, while impaired VEPs may be ascribed to a dysfunction of the visual pathways. The lack of correlation between VEPs impairment and EMS latency delay suggests that in our IDDM patients the delay of saccadic latency cannot be exclusively related to a visual pathways dysfunction and could be ascribed to a diffuse neuronal involvement.
本研究的目的是评估糖尿病患者的眼球快速运动与视觉通路功能之间是否存在相关性。对20例无长期并发症且代谢控制稳定的胰岛素依赖型糖尿病（IDDM）患者以及21名年龄匹配的对照受试者进行了眼球快速运动或快速眼动系统（EMS）和视觉诱发电位（VEP）评估。在IDDM患者中，我们观察到EMS潜伏期显著延长（p<0.01），而EMS速度和准确性与对照组相似；VEP显示N75、P100、N145潜伏期显著延迟，N75-P100和P100-N145波幅显著降低。在IDDM患者中，未发现EMS与VEP参数之间存在关联。总之，EMS潜伏期延迟表明眼球快速运动系统受损，而VEP受损可能归因于视觉通路功能障碍。VEP损伤与EMS潜伏期延迟之间缺乏相关性表明，在我们的IDDM患者中，眼球快速运动潜伏期延迟不能完全归因于视觉通路功能障碍，可能归因于弥漫性神经元受累。
