Brewer G J, Yuzbasiyan-Gurkan V, Johnson V, Dick R D, Wang Y
Am J Med Sci. 1993 Apr;305(4):199-202. doi: 10.1097/00000441-199304000-00001.
A considerable body of data is now available indicating the efficacy and lack of toxicity of zinc treatment of Wilson's disease. Dose-response studies have shown that regimens of 50 mg of elemental zinc 3 times a day (50 mg x 3), 25 mg x 3, and 50 mg x 2 are effective, but 25 mg x 2 and 50 mg x 1 are not adequately effective. These studies indicate that 75 mg a day is close to the minimally effective dose, but do not address the question of necessary dose frequency. In the current study, the authors have used the minimally effective daily dose, 75 mg, and studied this daily dose in regimens of 25 mg x 3, 37.5 mg x 2, and 75 mg x 1 in treatment of four patients with Wilson's disease. These data have been supplemented with additional data from 11 patients treated with 25 mg 3 times a day and with data from 2 patients treated with 75 mg once a day. Efficacy was evaluated by 10-day copper balance and absorption of orally administered 64copper. The findings indicate that a daily dose of 75 mg must be divided into at least two doses to be effective, and that the 64copper procedure is more sensitive to zinc dose than copper balance.
目前已有大量数据表明锌治疗威尔逊氏病的疗效及无毒性。剂量反应研究显示，每日3次服用50毫克元素锌（50毫克×3）、25毫克×3和50毫克×2的治疗方案有效，但25毫克×2和50毫克×1的方案效果欠佳。这些研究表明，每日75毫克接近最低有效剂量，但未涉及必要的给药频率问题。在当前研究中，作者采用最低有效日剂量75毫克，并以25毫克×3、37.5毫克×2和75毫克×1的方案对4例威尔逊氏病患者进行治疗研究。这些数据还补充了11例每日3次服用25毫克患者的额外数据以及2例每日服用1次75毫克患者的数据。通过10天铜平衡及口服64铜的吸收情况评估疗效。研究结果表明，每日75毫克剂量必须至少分为两剂服用才有效，且64铜检测方法对锌剂量比铜平衡更为敏感。
