Hoogenraad T U, Van den Hamer C J, Van Hattum J
Br Med J (Clin Res Ed). 1984 Aug 4;289(6440):273-6. doi: 10.1136/bmj.289.6440.273.
Most patients with Wilson's disease are treated with the potentially toxic cupriuretic agent penicillamine. The toxicity of zinc taken by mouth is low, and long term administration induces a negative copper balance. Two patients with severe neurological symptoms were given zinc sulphate by mouth three times daily in doses of 200 mg, later increased to 300 mg. One patient, a 21 year old man, started to receive zinc sulphate after his condition had deteriorated during treatment with cupriuretic drugs. The other, a 27 year old woman, was treated from the start with zinc sulphate. The conditions of both patients improved appreciably, and they were still receiving treatment with zinc sulphate roughly two years later. Effective depletion of body copper stores was shown by an intravenous radiocopper loading test and liver biopsy. No side effects were found. Wilson's disease may effectively be treated with zinc sulphate alone.
大多数威尔逊氏病患者接受具有潜在毒性的排铜剂青霉胺治疗。口服锌的毒性较低，长期服用可导致负铜平衡。两名有严重神经症状的患者每日口服硫酸锌3次，剂量为200毫克，后增至300毫克。一名21岁男性患者在用排铜药物治疗期间病情恶化后开始服用硫酸锌。另一名27岁女性患者从一开始就用硫酸锌治疗。两名患者的病情均有明显改善，大约两年后仍在接受硫酸锌治疗。静脉注射放射性铜负荷试验和肝活检显示体内铜储存有效耗竭。未发现副作用。威尔逊氏病单用硫酸锌可能有效治疗。
