Hill G M, Brewer G J, Prasad A S, Hydrick C R, Hartmann D E
Hepatology. 1987 May-Jun;7(3):522-8. doi: 10.1002/hep.1840070318.
The standard therapy for preventing copper accumulation in Wilson's disease, D-penicillamine, has been a life-saving drug, but it has many side effects and some patients are completely intolerant. We have been using oral zinc as another approach to the therapy for Wilson's disease, with copper balance studies as the key initial assessment of the adequacy of a given dose or regimen of zinc therapy. We earlier reported that an intensive regimen of zinc (zinc taken every 4 hr) was effective in controlling copper balance. We have now shown with balance studies that a simplified zinc therapy regimen of 50 mg zinc taken 3 times per day is effective in controlling copper balance. Preliminary work presented here with other simplified regimens also indicate their effectiveness. These studies increase the data base, in terms of copper balance, for zinc therapy of Wilson's disease, and expand the dose range and regimens of zinc which have been shown to control copper balance.
预防威尔逊氏病（肝豆状核变性）铜蓄积的标准疗法是使用D-青霉胺，它曾是一种挽救生命的药物，但有许多副作用，一些患者对其完全不耐受。我们一直在使用口服锌作为治疗威尔逊氏病的另一种方法，将铜平衡研究作为对给定剂量或锌治疗方案是否充分的关键初始评估。我们 earlier 报道，强化锌治疗方案（每4小时服用一次锌）在控制铜平衡方面是有效的。我们现在通过平衡研究表明，每天服用3次、每次50毫克锌的简化锌治疗方案在控制铜平衡方面是有效的。此处展示的关于其他简化方案的初步研究也表明了它们的有效性。这些研究增加了在铜平衡方面用于威尔逊氏病锌治疗的数据库，并扩大了已被证明能控制铜平衡的锌剂量范围和治疗方案。
