Spivak J L
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Annu Rev Med. 1993;44:243-53. doi: 10.1146/annurev.me.44.020193.001331.
Erythropoietin is the only hematopoietic growth factor that behaves like a hormone. Produced in the kidneys and the liver, erythropoietin interacts with erythroid progenitor cells in the bone marrow to promote their proliferation and maintain their viability. Erythropoietin production is regulated at the level of its gene by tissue oxygenation; hypoxia or anemia stimulates erythropoietin production, and erythrocytosis suppresses it, but never completely. The plasma erythropoietin concentration reflects erythropoietin production and can be used to define erythropoietin-deficient states in which anemia may be amenable to correction by administration of recombinant human erythropoietin.
促红细胞生成素是唯一一种表现得像激素的造血生长因子。促红细胞生成素在肾脏和肝脏中产生，它与骨髓中的红系祖细胞相互作用，以促进其增殖并维持其活力。促红细胞生成素的产生在其基因水平上受组织氧合作用调节；缺氧或贫血会刺激促红细胞生成素的产生，而红细胞增多症则会抑制它，但这种抑制从未完全彻底。血浆促红细胞生成素浓度反映了促红细胞生成素的产生情况，可用于定义促红细胞生成素缺乏状态，在这种状态下，贫血可能可通过给予重组人促红细胞生成素来纠正。
