肽和糖肽合成的最新进展。
Recent Departures in the Synthesis of Peptides and Glycopeptides.
作者信息
Kan Cindy, Danishefsky Samuel J
机构信息
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA.
出版信息
Tetrahedron. 2009 Nov 7;65(45):9047-9065. doi: 10.1016/j.tet.2009.09.032.
Abstract
In this account, we describe the results of a research program directed to the proposition that chemical synthesis can play a valuable role in identifying biologic level molecules worthy of pharma level development. We recount our journey towards the chemical synthesis of homogeneous erythropoietin, the challenges we encountered, and our efforts to address deficiencies in the current "state of the art" of glycopeptide synthesis. Here we describe new methods for the synthesis of glycopeptides that have emerged from the erythropoietin adventure, including the development of unique C-terminal acyl donors, novel amide bond forming methods, and new ligation and coupling strategies.
摘要
在本报告中，我们描述了一项研究计划的成果，该计划旨在验证化学合成在鉴定值得进行药物水平开发的生物级分子方面可发挥重要作用这一命题。我们讲述了我们在合成均一促红细胞生成素的化学合成过程中的历程、遇到的挑战，以及我们为弥补当前糖肽合成“技术水平”的不足所做的努力。在此，我们描述了从促红细胞生成素合成历程中涌现出的糖肽合成新方法，包括独特的C端酰基供体的开发、新型酰胺键形成方法以及新的连接和偶联策略。
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