Chyou P H, Nomura A M, Stemmermann G N, Kato I
Kuakini Medical Center, Honolulu, Hawaii.
Arch Environ Health. 1993 Mar-Apr;48(2):69-72. doi: 10.1080/00039896.1993.9938396.
A cohort study of lung cancer was conducted among 7,961 Japanese-American men who were interviewed and examined during 1965-1968. Information was collected about their smoking history, occupation, and nutrient intake. After 22 y, 227 incident cases of lung cancer were identified. Cigarette smoking significantly increased lung cancer risk. The relative risk (RR) was 3.1 for past smokers and 11.4 for current smokers, compared with never smokers. We separated lung cancer cases according to histological type, and it was found that current smokers had a RRs of 16.0 for squamous/small-cell carcinoma and 6.8 for adenocarcinoma of the lung. Unskilled manual workers had a significantly higher risk (RR = 1.5; 95% confidence interval, 1.1-2.2) for lung cancer than workers who were engaged in nonmanual occupations. There was no association between lung cancer and the 24-h intake of total calories, protein, fat, dietary cholesterol, carbohydrates, and alcohol, but this may have resulted from the limitations of a 24-h dietary questionnaire.
在1965年至1968年期间，对7961名日裔美国男性进行了一项肺癌队列研究。收集了他们的吸烟史、职业和营养摄入信息。22年后，确定了227例肺癌新发病例。吸烟显著增加肺癌风险。与从不吸烟者相比，既往吸烟者的相对风险（RR）为3.1，当前吸烟者为11.4。我们根据组织学类型对肺癌病例进行了分类，发现当前吸烟者患鳞状/小细胞癌的RR为16.0，患肺腺癌的RR为6.8。非技术体力劳动者患肺癌的风险（RR = 1.5；95%置信区间，1.1 - 2.2）显著高于从事非体力职业的劳动者。肺癌与24小时总热量、蛋白质、脂肪、膳食胆固醇、碳水化合物和酒精的摄入量之间没有关联，但这可能是由于24小时膳食问卷的局限性所致。
